Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer

Ji Hoon Yu, Hyeyoung Kim

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

In the pathogenesis of pancreatitis, oxidative stress is involved in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and cytokine expression. High serum levels of cholecystokinin (CCK) have been reported in patients with acute pancreatitis, and treatment with cerulein, a CCK analogue, induces acute pancreatitis in a rodent model. Recent studies have shown that cerulein-activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species, which trigger the phosphorylation of the JAK1, STAT1, and STAT3 proteins and induce the production of inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, in pancreatic acinar cells. The JAK/STAT pathway also stimulates cell proliferation and malignant transformation and inhibits apoptosis in the pancreas. This review discusses the possible role of the JAK/STAT pathway in the pathogenesis of pancreatitis and pancreatic cancer in response to oxidative stress.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalGut and liver
Volume6
Issue number4
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Janus Kinases
Transducers
Pancreatic Neoplasms
Pancreatitis
Ceruletide
Cholecystokinin
Oxidative Stress
STAT1 Transcription Factor
Cytokines
STAT3 Transcription Factor
Acinar Cells
Interleukin-1
NADP
Pancreas
Rodentia
Interleukin-6
Reactive Oxygen Species
Oxidoreductases
Tumor Necrosis Factor-alpha
Phosphorylation

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

@article{4e7337908b984036b68a7cbcf02298cb,
title = "Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer",
abstract = "In the pathogenesis of pancreatitis, oxidative stress is involved in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and cytokine expression. High serum levels of cholecystokinin (CCK) have been reported in patients with acute pancreatitis, and treatment with cerulein, a CCK analogue, induces acute pancreatitis in a rodent model. Recent studies have shown that cerulein-activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species, which trigger the phosphorylation of the JAK1, STAT1, and STAT3 proteins and induce the production of inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, in pancreatic acinar cells. The JAK/STAT pathway also stimulates cell proliferation and malignant transformation and inhibits apoptosis in the pancreas. This review discusses the possible role of the JAK/STAT pathway in the pathogenesis of pancreatitis and pancreatic cancer in response to oxidative stress.",
author = "Yu, {Ji Hoon} and Hyeyoung Kim",
year = "2012",
month = "10",
day = "1",
doi = "10.5009/gnl.2012.6.4.417",
language = "English",
volume = "6",
pages = "417--422",
journal = "Gut and Liver",
issn = "1976-2283",
publisher = "Joe Bok Chung",
number = "4",

}

Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer. / Yu, Ji Hoon; Kim, Hyeyoung.

In: Gut and liver, Vol. 6, No. 4, 01.10.2012, p. 417-422.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer

AU - Yu, Ji Hoon

AU - Kim, Hyeyoung

PY - 2012/10/1

Y1 - 2012/10/1

N2 - In the pathogenesis of pancreatitis, oxidative stress is involved in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and cytokine expression. High serum levels of cholecystokinin (CCK) have been reported in patients with acute pancreatitis, and treatment with cerulein, a CCK analogue, induces acute pancreatitis in a rodent model. Recent studies have shown that cerulein-activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species, which trigger the phosphorylation of the JAK1, STAT1, and STAT3 proteins and induce the production of inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, in pancreatic acinar cells. The JAK/STAT pathway also stimulates cell proliferation and malignant transformation and inhibits apoptosis in the pancreas. This review discusses the possible role of the JAK/STAT pathway in the pathogenesis of pancreatitis and pancreatic cancer in response to oxidative stress.

AB - In the pathogenesis of pancreatitis, oxidative stress is involved in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and cytokine expression. High serum levels of cholecystokinin (CCK) have been reported in patients with acute pancreatitis, and treatment with cerulein, a CCK analogue, induces acute pancreatitis in a rodent model. Recent studies have shown that cerulein-activated nicotinamide adenine dinucleotide phosphate oxidase elicits reactive oxygen species, which trigger the phosphorylation of the JAK1, STAT1, and STAT3 proteins and induce the production of inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, in pancreatic acinar cells. The JAK/STAT pathway also stimulates cell proliferation and malignant transformation and inhibits apoptosis in the pancreas. This review discusses the possible role of the JAK/STAT pathway in the pathogenesis of pancreatitis and pancreatic cancer in response to oxidative stress.

UR - http://www.scopus.com/inward/record.url?scp=84868145988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868145988&partnerID=8YFLogxK

U2 - 10.5009/gnl.2012.6.4.417

DO - 10.5009/gnl.2012.6.4.417

M3 - Review article

C2 - 23170143

AN - SCOPUS:84868145988

VL - 6

SP - 417

EP - 422

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - 4

ER -