Role of miRNAs in bone and their potential as therapeutic targets

Kyoung Min Kim, Sung Kil Lim

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are noncoding, single-stranded RNAs that regulate the expression of target genes by binding their 3′-untranslated region. miRNAs are important regulators of various biological processes, including cellular differentiation, proliferation, apoptosis, and tissue development. Furthermore, aberrant miRNA expression has emerged as an important pathomechanism in various human diseases, including osteoporosis. Thus, the therapeutic potential of miRNA has attracted great interest recently. Here, we focused on the roles of miRNAs in bone homeostasis and the potential of miRNAs as therapeutic targets.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalCurrent Opinion in Pharmacology
Volume16
Issue number1
DOIs
Publication statusPublished - 2014 Jun

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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