Role of oxygen free radicals in patients with acute pancreatitis

Byung Kyu Park, Jae Bock Chung, Jin Heon Lee, Jeong Hun Suh, Seung Woo Park, Si Young Song, Hye Young Kim, Kyung Hwan Kim, Jin Kyung Kang

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Aim: The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis. Methods: The plasma levels of C-reactive protein (CRP), lipid peroxide (LPO), myeloperoxidase (MPO) and superoxide dismutase (SOD) were measured in 13 patients with acute pancreatitis and 14 healthy volunteers. Results: Among the patients with acute pancreatitis, there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild pancreatitis. However, there was no significant difference in the serum marker of oxidative stress no matter what the etiology was. The LPO level was especially correlated with the concentration of serum CRP and CT severity index. Conclusion: The oxygen free radicals may be closely associated with inflammatory process and the severity of acute pancreatitis. Especially, the concentration of plasma LPO is a meaningful index for determining the severity of the disease.

Original languageEnglish
Pages (from-to)2266-2269
Number of pages4
JournalWorld Journal of Gastroenterology
Volume9
Issue number10
DOIs
Publication statusPublished - 2003 Jan 1

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Pancreatitis
Free Radicals
Reactive Oxygen Species
Lipid Peroxides
C-Reactive Protein
Peroxidase
Superoxide Dismutase
Blood Proteins
Healthy Volunteers
Oxidative Stress
Biomarkers

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Park, B. K., Chung, J. B., Lee, J. H., Suh, J. H., Park, S. W., Song, S. Y., ... Kang, J. K. (2003). Role of oxygen free radicals in patients with acute pancreatitis. World Journal of Gastroenterology, 9(10), 2266-2269. https://doi.org/10.3748/wjg.v9.i10.2266
Park, Byung Kyu ; Chung, Jae Bock ; Lee, Jin Heon ; Suh, Jeong Hun ; Park, Seung Woo ; Song, Si Young ; Kim, Hye Young ; Kim, Kyung Hwan ; Kang, Jin Kyung. / Role of oxygen free radicals in patients with acute pancreatitis. In: World Journal of Gastroenterology. 2003 ; Vol. 9, No. 10. pp. 2266-2269.
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Park, BK, Chung, JB, Lee, JH, Suh, JH, Park, SW, Song, SY, Kim, HY, Kim, KH & Kang, JK 2003, 'Role of oxygen free radicals in patients with acute pancreatitis', World Journal of Gastroenterology, vol. 9, no. 10, pp. 2266-2269. https://doi.org/10.3748/wjg.v9.i10.2266

Role of oxygen free radicals in patients with acute pancreatitis. / Park, Byung Kyu; Chung, Jae Bock; Lee, Jin Heon; Suh, Jeong Hun; Park, Seung Woo; Song, Si Young; Kim, Hye Young; Kim, Kyung Hwan; Kang, Jin Kyung.

In: World Journal of Gastroenterology, Vol. 9, No. 10, 01.01.2003, p. 2266-2269.

Research output: Contribution to journalArticle

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Park BK, Chung JB, Lee JH, Suh JH, Park SW, Song SY et al. Role of oxygen free radicals in patients with acute pancreatitis. World Journal of Gastroenterology. 2003 Jan 1;9(10):2266-2269. https://doi.org/10.3748/wjg.v9.i10.2266