Approximately 30% to 40% of patients with diffuse large B-cell lymphoma (DLBCL) will have either primary refractory disease or relapse after chemotherapy. In transplant-eligible patients, those with disease sensitive to salvage chemotherapy will significantly benefit from high-dose therapy with autologous stem cell transplantation. The rationale for considering radiation therapy (RT) for selected patients with relapsed/refractory DLBCL as a part of the salvage program is based on data regarding the patterns of relapse and retrospective series showing improved local control and clinical outcomes for patients who received peritransplant RT. In transplant-ineligible patients, RT can provide effective palliation and, in selected cases, be administered with curative intent if the relapsed/refractory disease is localized. We have reviewed the indications for RT in the setting of relapsed/refractory DLBCL and provided recommendations regarding the optimal timing of RT, dose fractionation scheme, and treatment volume in the context of specific case scenarios.
|Number of pages||18|
|Journal||International Journal of Radiation Oncology Biology Physics|
|Publication status||Published - 2018 Mar 1|
Bibliographical noteFunding Information:
Conflict of interest: Dr Davies reports grants, personal fees, and nonfinancial support from F. Hoffmann La-Roche; grants and personal fees from Celgene; grants, personal fees, and nonfinancial support from Gilead Pharma; grants, personal fees, and nonfinancial support from Takeda; personal fees and nonfinancial support from CTI; personal fees and nonfinancial support from Mundipharma; grants from GSK; grants from Janssen; grants and personal fees from Pfizer; grants and personal fees from Karyopharma; and grants from Acerta; outside the submitted work. Dr Specht reports personal fees and nonfinancial support from Takeda, personal fees from Merck, and grants from Varian, outside the submitted work.
© 2017 Elsevier Inc.
All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
- Cancer Research