Role of specific IgE on staphylococcal enterotoxin B in chronic rhinosinusitis severity

Suk Won Chang, Jeong Jin Park, Chi Sang Hwang, Jae Sung Nam, Jong Gyun Ha, Wasan F. Almarzouq, Chang Hoon Kim, Joo Heon Yoon, Hyung Ju Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the clinical significance of specific IgE-staphylococcal enterotoxin B (IgE-SEB) in CRS (chronic rhinosinusitis). Design: Retrospective analysis of patients who were positive for specific IgE-staphylococcal enterotoxin B. Setting: Tertiary rhinology clinic. Participants: A total of 965 patients who were tested for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017. Main outcome measures: We retrospectively reviewed the records of 965 patients who were tested for specific IgE-staphylococcal enterotoxin B from December 2016 to December 2017. Patient demographics, titre-specific IgE to staphylococcal enterotoxin B levels, MAST, serologic test and medical records were reviewed. Results: IgE-SEB (KU/L) was higher in CRS patients than non-CRS patients (0.13 ± 0.37 vs 0.08 ± 0.22, respectively; P-value:.044), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 4.46%, respectively; P-value:.030). IgE-SEB (KU/L) was higher in the CRS group than in the fungal sinusitis group (0.13 ± 0.37 vs 0.03 ± 0.05, respectively; P-value: <.001), and the IgE-SEB (+, ≥0.35) rate was also higher (10.06% vs 0%, respectively; P-value:.015). Between the CRSsNP (chronic rhinosinusitis without nasal polyps) and CRSwNP (chronic rhinosinusitis with nasal polyps) groups, there were no differences in IgE-SEB (KU/L) or IgE-SEB (+) rates. IgE-SEB positivity was not associated with the presence of polyps, concomitant asthma or postoperative recurrence. As the values of IgE-SEB (KU/L) and the IgE-SEB (+, >0.1) rate increased, the CRS severity also increased. Conclusions: IgE-SEB showed a positive correlation with Lund-Mackay CT severity score, but not with postoperative recurrence or nasal polyps. Further studies are needed to obtain clear evidence that IgE-SEB can be considered as an independent CRS endotype.

Original languageEnglish
JournalClinical Otolaryngology
DOIs
Publication statusAccepted/In press - 2020

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF‐2018R1D1A1A02049236) to HJ Cho. This study was supported by a Faculty Research Grant of Yonsei University College of Medicine to HJ Cho (6‐2018‐0167). This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the ministry of Science, ICT & Future Planning (NRF‐2016M3A9D5A01952414).

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Role of specific IgE on staphylococcal enterotoxin B in chronic rhinosinusitis severity'. Together they form a unique fingerprint.

Cite this