Role of 18F-FDG PET scans in patients with Helicobacter pylori-infected gastric low-grade MALT lymphoma

Kyung Ho Song, Mijin Yun, Jie-Hyun Kim, Woo Ick Yang, Dae Ryong Kang, Jae Bock Chung, Yongchan Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Aims: Endoscopic ultrasound (EUS) plays a crucial role in the assessment and treatment of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma; however, interobserver variation, inadequate accuracy in judging the depth of tumor invasion, and histological heterogeneity of the tumor can limit its role. Thus, we have assessed the role of 18F-FDG PET scans in the management of Helicobacter pylori-infected gastric MALT lymphoma. Methods: Eighteen patients with H. pylori-infected low-grade gastric MALT lymphoma underwent an 18F-FDG PET scan prior to receiving H. pylori eradication therapy. We analyzed these patients' clinicopathologic data and measured the baseline and change in the metabolic activity of the tumor using standardized uptake values (SUVs). Results: Two patients failed to achieve complete remission of the low-grade gastric MALT lymphoma after successful H. pylori eradication. The baseline SUVs were significantly higher in these patients compared to successfully treated patients, 13.35±0.07 vs 2.98±0.93, respectively (n=2 vs n=16, p<0.001). The reduction in the SUV was significantly greater in the complete remission patients compared to treatment failure patients (p=0.018). Conclusions: A high SUV at baseline 18F-FDG PET and a lower reduction in the SUV within 3 months after eradication therapy are associated with treatment failure in H. pylori-positive low-grade gastric MALT lymphoma patients undergoing eradication treatment.

Original languageEnglish
Pages (from-to)308-314
Number of pages7
JournalGut and Liver
Volume5
Issue number3
DOIs
Publication statusPublished - 2011 Sep 1

Fingerprint

Marginal Zone B-Cell Lymphoma
Fluorodeoxyglucose F18
Helicobacter pylori
Positron-Emission Tomography
Non-Hodgkin's Lymphoma
Stomach
Gastric Mucosa
Treatment Failure
Neoplasms
Observer Variation
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Song, Kyung Ho ; Yun, Mijin ; Kim, Jie-Hyun ; Yang, Woo Ick ; Kang, Dae Ryong ; Chung, Jae Bock ; Lee, Yongchan. / Role of 18F-FDG PET scans in patients with Helicobacter pylori-infected gastric low-grade MALT lymphoma. In: Gut and Liver. 2011 ; Vol. 5, No. 3. pp. 308-314.
@article{b4f0e16378714b8da2dc7eb3cb94c91c,
title = "Role of 18F-FDG PET scans in patients with Helicobacter pylori-infected gastric low-grade MALT lymphoma",
abstract = "Background/Aims: Endoscopic ultrasound (EUS) plays a crucial role in the assessment and treatment of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma; however, interobserver variation, inadequate accuracy in judging the depth of tumor invasion, and histological heterogeneity of the tumor can limit its role. Thus, we have assessed the role of 18F-FDG PET scans in the management of Helicobacter pylori-infected gastric MALT lymphoma. Methods: Eighteen patients with H. pylori-infected low-grade gastric MALT lymphoma underwent an 18F-FDG PET scan prior to receiving H. pylori eradication therapy. We analyzed these patients' clinicopathologic data and measured the baseline and change in the metabolic activity of the tumor using standardized uptake values (SUVs). Results: Two patients failed to achieve complete remission of the low-grade gastric MALT lymphoma after successful H. pylori eradication. The baseline SUVs were significantly higher in these patients compared to successfully treated patients, 13.35±0.07 vs 2.98±0.93, respectively (n=2 vs n=16, p<0.001). The reduction in the SUV was significantly greater in the complete remission patients compared to treatment failure patients (p=0.018). Conclusions: A high SUV at baseline 18F-FDG PET and a lower reduction in the SUV within 3 months after eradication therapy are associated with treatment failure in H. pylori-positive low-grade gastric MALT lymphoma patients undergoing eradication treatment.",
author = "Song, {Kyung Ho} and Mijin Yun and Jie-Hyun Kim and Yang, {Woo Ick} and Kang, {Dae Ryong} and Chung, {Jae Bock} and Yongchan Lee",
year = "2011",
month = "9",
day = "1",
doi = "10.5009/gnl.2011.5.3.308",
language = "English",
volume = "5",
pages = "308--314",
journal = "Gut and Liver",
issn = "1976-2283",
publisher = "Joe Bok Chung",
number = "3",

}

Role of 18F-FDG PET scans in patients with Helicobacter pylori-infected gastric low-grade MALT lymphoma. / Song, Kyung Ho; Yun, Mijin; Kim, Jie-Hyun; Yang, Woo Ick; Kang, Dae Ryong; Chung, Jae Bock; Lee, Yongchan.

In: Gut and Liver, Vol. 5, No. 3, 01.09.2011, p. 308-314.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of 18F-FDG PET scans in patients with Helicobacter pylori-infected gastric low-grade MALT lymphoma

AU - Song, Kyung Ho

AU - Yun, Mijin

AU - Kim, Jie-Hyun

AU - Yang, Woo Ick

AU - Kang, Dae Ryong

AU - Chung, Jae Bock

AU - Lee, Yongchan

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Background/Aims: Endoscopic ultrasound (EUS) plays a crucial role in the assessment and treatment of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma; however, interobserver variation, inadequate accuracy in judging the depth of tumor invasion, and histological heterogeneity of the tumor can limit its role. Thus, we have assessed the role of 18F-FDG PET scans in the management of Helicobacter pylori-infected gastric MALT lymphoma. Methods: Eighteen patients with H. pylori-infected low-grade gastric MALT lymphoma underwent an 18F-FDG PET scan prior to receiving H. pylori eradication therapy. We analyzed these patients' clinicopathologic data and measured the baseline and change in the metabolic activity of the tumor using standardized uptake values (SUVs). Results: Two patients failed to achieve complete remission of the low-grade gastric MALT lymphoma after successful H. pylori eradication. The baseline SUVs were significantly higher in these patients compared to successfully treated patients, 13.35±0.07 vs 2.98±0.93, respectively (n=2 vs n=16, p<0.001). The reduction in the SUV was significantly greater in the complete remission patients compared to treatment failure patients (p=0.018). Conclusions: A high SUV at baseline 18F-FDG PET and a lower reduction in the SUV within 3 months after eradication therapy are associated with treatment failure in H. pylori-positive low-grade gastric MALT lymphoma patients undergoing eradication treatment.

AB - Background/Aims: Endoscopic ultrasound (EUS) plays a crucial role in the assessment and treatment of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma; however, interobserver variation, inadequate accuracy in judging the depth of tumor invasion, and histological heterogeneity of the tumor can limit its role. Thus, we have assessed the role of 18F-FDG PET scans in the management of Helicobacter pylori-infected gastric MALT lymphoma. Methods: Eighteen patients with H. pylori-infected low-grade gastric MALT lymphoma underwent an 18F-FDG PET scan prior to receiving H. pylori eradication therapy. We analyzed these patients' clinicopathologic data and measured the baseline and change in the metabolic activity of the tumor using standardized uptake values (SUVs). Results: Two patients failed to achieve complete remission of the low-grade gastric MALT lymphoma after successful H. pylori eradication. The baseline SUVs were significantly higher in these patients compared to successfully treated patients, 13.35±0.07 vs 2.98±0.93, respectively (n=2 vs n=16, p<0.001). The reduction in the SUV was significantly greater in the complete remission patients compared to treatment failure patients (p=0.018). Conclusions: A high SUV at baseline 18F-FDG PET and a lower reduction in the SUV within 3 months after eradication therapy are associated with treatment failure in H. pylori-positive low-grade gastric MALT lymphoma patients undergoing eradication treatment.

UR - http://www.scopus.com/inward/record.url?scp=80052486168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80052486168&partnerID=8YFLogxK

U2 - 10.5009/gnl.2011.5.3.308

DO - 10.5009/gnl.2011.5.3.308

M3 - Article

C2 - 21927659

AN - SCOPUS:80052486168

VL - 5

SP - 308

EP - 314

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - 3

ER -