Root coverage using porcine collagen matrix with fibroblast growth factor-2: a pilot study in dogs

Jae Kook Cha, Yoo Kyung Sun, Jung Seok Lee, Seongho Choi, Ui-Won Jung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: The aim of this study was to evaluate the effect of fibroblast growth factor-2 (FGF-2) in combination with porcine collagen matrix (CM) for coverage of gingival recession defects in dogs. Materials and Methods: In five male mongrel dogs, labial gingival recession defects were surgically created in the lower-third incisors bilaterally. The defects were randomly assigned to the CM/FGF-2 group (experimental) or the CM-only group (control). Standardized clinical photographs and silicone impressions were taken at 4 and 16 weeks of healing to calculate the remaining recession area. The dogs were euthanized after 16 weeks for histometric analysis. Results: At 4 weeks, the recession area of the CM/FGF-2 group was significantly smaller than that of the CM-only group (2.55 ± 0.66 and 4.92 ± 1.05 mm2, respectively, p = 0.023), However, no significant difference was observed at 16 weeks. Histometrically, the amount of newly formed cementum was larger in the CM/FGF-2 group than in the CM-only group at 16 weeks (1.55 ± 0.44 and 0.88 ± 0.51 mm, respectively, p = 0.024). Conclusions: The combination of CM/FGF-2 may enhance the early wound healing and may promote cementum formation to a higher extent compared to the use of CM alone.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalJournal of Clinical Periodontology
Volume44
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Fibroblast Growth Factor 2
Swine
Collagen
Dogs
Gingival Recession
Dental Cementum
Silicones
Incisor
Lip
Wound Healing
Control Groups

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

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title = "Root coverage using porcine collagen matrix with fibroblast growth factor-2: a pilot study in dogs",
abstract = "Aim: The aim of this study was to evaluate the effect of fibroblast growth factor-2 (FGF-2) in combination with porcine collagen matrix (CM) for coverage of gingival recession defects in dogs. Materials and Methods: In five male mongrel dogs, labial gingival recession defects were surgically created in the lower-third incisors bilaterally. The defects were randomly assigned to the CM/FGF-2 group (experimental) or the CM-only group (control). Standardized clinical photographs and silicone impressions were taken at 4 and 16 weeks of healing to calculate the remaining recession area. The dogs were euthanized after 16 weeks for histometric analysis. Results: At 4 weeks, the recession area of the CM/FGF-2 group was significantly smaller than that of the CM-only group (2.55 ± 0.66 and 4.92 ± 1.05 mm2, respectively, p = 0.023), However, no significant difference was observed at 16 weeks. Histometrically, the amount of newly formed cementum was larger in the CM/FGF-2 group than in the CM-only group at 16 weeks (1.55 ± 0.44 and 0.88 ± 0.51 mm, respectively, p = 0.024). Conclusions: The combination of CM/FGF-2 may enhance the early wound healing and may promote cementum formation to a higher extent compared to the use of CM alone.",
author = "Cha, {Jae Kook} and Sun, {Yoo Kyung} and Lee, {Jung Seok} and Seongho Choi and Ui-Won Jung",
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Root coverage using porcine collagen matrix with fibroblast growth factor-2 : a pilot study in dogs. / Cha, Jae Kook; Sun, Yoo Kyung; Lee, Jung Seok; Choi, Seongho; Jung, Ui-Won.

In: Journal of Clinical Periodontology, Vol. 44, No. 1, 01.01.2017, p. 96-103.

Research output: Contribution to journalArticle

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