Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

Bo Ram Jin, Kyung Sook Chung, Se Yun Cheon, Minho Lee, Soonjae Hwang, Sam Noh Hwang, Kijong Rhee, Hyo Jin An

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Ulcerative colitis (UC), a type of inflammatory bowel disease (IBD), is a chronic inflammatory disorder of the colon. Although UC is generally treated with anti-inflammatory drugs or immunosuppressants, most of these treatments often prove to be inadequate. Rosmarinic acid (RA) is a phenolic ester included in various medicinal herbs such as Salvia miltiorrhiz and Perilla frutescens. Although RA has many biological and pharmacological activities, the anti-inflammatory effect of RA in colonic tissue remains unclear. In this study, we investigated the anti-inflammatory effects and underlying molecular mechanism of RA in mice with dextran sulphate sodium (DSS)-induced colitis. In the DSS-induced colitis model, RA significantly reduced the severity of colitis, as assessed by disease activity index (DAI) scores, colonic damage, and colon length. In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1β, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis. Furthermore, RA effectively and pleiotropically inhibited nuclear factor-kappa B and signal transducer and activator of transcription 3 activation, and subsequently reduced the activity of pro-survival genes that depend on these transcription factors. These results demonstrate that RA has an ameliorative effect on colonic inflammation and thus a potential therapeutic role in colitis.

Original languageEnglish
Article number46252
JournalScientific reports
Volume7
DOIs
Publication statusPublished - 2017 Apr 6

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Dextran Sulfate
Inflammation
Colitis
Anti-Inflammatory Agents
Ulcerative Colitis
Perilla frutescens
Colon
Salvia
STAT3 Transcription Factor
rosmarinic acid
NF-kappa B
Immunosuppressive Agents
Medicinal Plants
Interleukin-1
Transcriptional Activation
Interleukin-6
Esters
Transcription Factors
Pharmacology
Cytokines

All Science Journal Classification (ASJC) codes

  • General

Cite this

Jin, Bo Ram ; Chung, Kyung Sook ; Cheon, Se Yun ; Lee, Minho ; Hwang, Soonjae ; Noh Hwang, Sam ; Rhee, Kijong ; An, Hyo Jin. / Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation. In: Scientific reports. 2017 ; Vol. 7.
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Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation. / Jin, Bo Ram; Chung, Kyung Sook; Cheon, Se Yun; Lee, Minho; Hwang, Soonjae; Noh Hwang, Sam; Rhee, Kijong; An, Hyo Jin.

In: Scientific reports, Vol. 7, 46252, 06.04.2017.

Research output: Contribution to journalArticle

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AU - Chung, Kyung Sook

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AU - Lee, Minho

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AU - Noh Hwang, Sam

AU - Rhee, Kijong

AU - An, Hyo Jin

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