Round window membrane vibration may increase the effect of intratympanic dexamethasone injection

Soon Hyung Park, InSeok Moon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives/Hypothesis We investigated whether the round window membrane (RWM) vibration can facilitate dexamethasone perfusion via the RWM in patients with sudden hearing loss. Study Design Prospective study. Methods We first performed an in vitro study using a semipermeable membrane. In the subsequent in vivo study, 20 mice were randomized into two groups: an intratympanic dexamethasone injection (ITDI)-only group, and an ITDI with RWM vibration group. Concentration of dexamethasone was investigated using high performance liquid chromatography. Third, we performed a prospective clinical study. Fifty-five refractory sudden hearing loss patients were divided into two groups: those who received ITDI only (n-=-36) and those who received ITDI with RWM vibration (n-=-19). Final hearing assessments were conducted 2 months after salvage treatment. Results In the in vitro study, the concentration of dexamethasone increased with vibration time with the peak concentration observed at 3 minutes of vibration. In the in vivo study, ITDI with RWM vibration resulted in a significantly higher perilymph concentration of dexamethasone (7.68-±-3.13 μg/ml) than that in the ITDI-only group (2.66-±-1.73 μg/ml). In a clinical setting, the overall improvement in hearing was similar between the two groups. However, when we compared the speech discrimination score between the two groups, we found that the relative discrimination gain in the ITDI with RWM vibration group (18.11-±-23.54%) was higher than that in the ITDI-only group (7.00-±-15.54%) (P-=-0.042). Conclusion RWM vibration can enhance the effect of intratympanic dexamethasone injection and is a viable treatment option for sudden hearing loss. Levels of Evidence N/A. Laryngoscope, 124:1444-1451, 2014

Original languageEnglish
Pages (from-to)1444-1451
Number of pages8
JournalLaryngoscope
Volume124
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Vibration
Dexamethasone
Membranes
Sudden Hearing Loss
Intratympanic Injection
Hearing
Prospective Studies
Perilymph
Laryngoscopes
Salvage Therapy
Speech Perception
Perfusion
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

@article{c6a34786160644e490fb880dd5dbc9c1,
title = "Round window membrane vibration may increase the effect of intratympanic dexamethasone injection",
abstract = "Objectives/Hypothesis We investigated whether the round window membrane (RWM) vibration can facilitate dexamethasone perfusion via the RWM in patients with sudden hearing loss. Study Design Prospective study. Methods We first performed an in vitro study using a semipermeable membrane. In the subsequent in vivo study, 20 mice were randomized into two groups: an intratympanic dexamethasone injection (ITDI)-only group, and an ITDI with RWM vibration group. Concentration of dexamethasone was investigated using high performance liquid chromatography. Third, we performed a prospective clinical study. Fifty-five refractory sudden hearing loss patients were divided into two groups: those who received ITDI only (n-=-36) and those who received ITDI with RWM vibration (n-=-19). Final hearing assessments were conducted 2 months after salvage treatment. Results In the in vitro study, the concentration of dexamethasone increased with vibration time with the peak concentration observed at 3 minutes of vibration. In the in vivo study, ITDI with RWM vibration resulted in a significantly higher perilymph concentration of dexamethasone (7.68-±-3.13 μg/ml) than that in the ITDI-only group (2.66-±-1.73 μg/ml). In a clinical setting, the overall improvement in hearing was similar between the two groups. However, when we compared the speech discrimination score between the two groups, we found that the relative discrimination gain in the ITDI with RWM vibration group (18.11-±-23.54{\%}) was higher than that in the ITDI-only group (7.00-±-15.54{\%}) (P-=-0.042). Conclusion RWM vibration can enhance the effect of intratympanic dexamethasone injection and is a viable treatment option for sudden hearing loss. Levels of Evidence N/A. Laryngoscope, 124:1444-1451, 2014",
author = "Park, {Soon Hyung} and InSeok Moon",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/lary.24482",
language = "English",
volume = "124",
pages = "1444--1451",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

Round window membrane vibration may increase the effect of intratympanic dexamethasone injection. / Park, Soon Hyung; Moon, InSeok.

In: Laryngoscope, Vol. 124, No. 6, 01.01.2014, p. 1444-1451.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Round window membrane vibration may increase the effect of intratympanic dexamethasone injection

AU - Park, Soon Hyung

AU - Moon, InSeok

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objectives/Hypothesis We investigated whether the round window membrane (RWM) vibration can facilitate dexamethasone perfusion via the RWM in patients with sudden hearing loss. Study Design Prospective study. Methods We first performed an in vitro study using a semipermeable membrane. In the subsequent in vivo study, 20 mice were randomized into two groups: an intratympanic dexamethasone injection (ITDI)-only group, and an ITDI with RWM vibration group. Concentration of dexamethasone was investigated using high performance liquid chromatography. Third, we performed a prospective clinical study. Fifty-five refractory sudden hearing loss patients were divided into two groups: those who received ITDI only (n-=-36) and those who received ITDI with RWM vibration (n-=-19). Final hearing assessments were conducted 2 months after salvage treatment. Results In the in vitro study, the concentration of dexamethasone increased with vibration time with the peak concentration observed at 3 minutes of vibration. In the in vivo study, ITDI with RWM vibration resulted in a significantly higher perilymph concentration of dexamethasone (7.68-±-3.13 μg/ml) than that in the ITDI-only group (2.66-±-1.73 μg/ml). In a clinical setting, the overall improvement in hearing was similar between the two groups. However, when we compared the speech discrimination score between the two groups, we found that the relative discrimination gain in the ITDI with RWM vibration group (18.11-±-23.54%) was higher than that in the ITDI-only group (7.00-±-15.54%) (P-=-0.042). Conclusion RWM vibration can enhance the effect of intratympanic dexamethasone injection and is a viable treatment option for sudden hearing loss. Levels of Evidence N/A. Laryngoscope, 124:1444-1451, 2014

AB - Objectives/Hypothesis We investigated whether the round window membrane (RWM) vibration can facilitate dexamethasone perfusion via the RWM in patients with sudden hearing loss. Study Design Prospective study. Methods We first performed an in vitro study using a semipermeable membrane. In the subsequent in vivo study, 20 mice were randomized into two groups: an intratympanic dexamethasone injection (ITDI)-only group, and an ITDI with RWM vibration group. Concentration of dexamethasone was investigated using high performance liquid chromatography. Third, we performed a prospective clinical study. Fifty-five refractory sudden hearing loss patients were divided into two groups: those who received ITDI only (n-=-36) and those who received ITDI with RWM vibration (n-=-19). Final hearing assessments were conducted 2 months after salvage treatment. Results In the in vitro study, the concentration of dexamethasone increased with vibration time with the peak concentration observed at 3 minutes of vibration. In the in vivo study, ITDI with RWM vibration resulted in a significantly higher perilymph concentration of dexamethasone (7.68-±-3.13 μg/ml) than that in the ITDI-only group (2.66-±-1.73 μg/ml). In a clinical setting, the overall improvement in hearing was similar between the two groups. However, when we compared the speech discrimination score between the two groups, we found that the relative discrimination gain in the ITDI with RWM vibration group (18.11-±-23.54%) was higher than that in the ITDI-only group (7.00-±-15.54%) (P-=-0.042). Conclusion RWM vibration can enhance the effect of intratympanic dexamethasone injection and is a viable treatment option for sudden hearing loss. Levels of Evidence N/A. Laryngoscope, 124:1444-1451, 2014

UR - http://www.scopus.com/inward/record.url?scp=84901660366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901660366&partnerID=8YFLogxK

U2 - 10.1002/lary.24482

DO - 10.1002/lary.24482

M3 - Article

VL - 124

SP - 1444

EP - 1451

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 6

ER -