rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries

Lishi Qian, Chiyoji Abe, Tao Ping Lin, Ming Chih Yu, Sangnae Cho, Sumin Wang, James T. Douglas

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Abstract

The 81-bp region of the rpoB gene in 66 Rif Mycobacterium tuberculosis isolates from China, Japan, Korea, and Taiwan was analyzed. Twelve single-nucleotide substitutions in the rpoB gene were detected. The most prevalent mutations were at Ser-531 (52%), Asp-516 (17%), and His-526 (11%). Mutations were not found in seven (11%) of the isolates. Higher mutation rates in 50 Beijing family isolates were found than in other isolates for mutations at Asp-516 (18 and 12.5%, respectively) and His-526 (12 and 6.3%, respectively). The different rates of mutation may reflect the choice of rifamycin analogs.

Original languageEnglish
Pages (from-to)1091-1094
Number of pages4
JournalJournal of Clinical Microbiology
Volume40
Issue number3
DOIs
Publication statusPublished - 2002 Mar 20

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Mycobacterium tuberculosis
Genotype
Mutation Rate
Mutation
Korea
Taiwan
Genes
China
Japan
Nucleotides
Beijing

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Microbiology

Cite this

Qian, Lishi ; Abe, Chiyoji ; Lin, Tao Ping ; Yu, Ming Chih ; Cho, Sangnae ; Wang, Sumin ; Douglas, James T. / rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries. In: Journal of Clinical Microbiology. 2002 ; Vol. 40, No. 3. pp. 1091-1094.
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rpoB genotypes of Mycobacterium tuberculosis Beijing family isolates from East Asian countries. / Qian, Lishi; Abe, Chiyoji; Lin, Tao Ping; Yu, Ming Chih; Cho, Sangnae; Wang, Sumin; Douglas, James T.

In: Journal of Clinical Microbiology, Vol. 40, No. 3, 20.03.2002, p. 1091-1094.

Research output: Contribution to journalArticle

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AU - Douglas, James T.

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