Abstract
A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized. Copyright
| Original language | English |
|---|---|
| Pages (from-to) | 320-324 |
| Number of pages | 5 |
| Journal | Tuberculosis and Respiratory Diseases |
| Volume | 73 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2012 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Infectious Diseases
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Sarcoidosis presenting with massive pleural effusion and elevated serum and pleural fluid carbohydrate antigen-125 levels. / Lee, In Seon; Kim, Sae Byul; Moon, Chan Soo; Jung, Sung Mo; Kim, Song Yee; Kim, Eun Young; Jung, Ji Ye; kang, youngae; Kim, Young Sam; Kim, Se Kyu; Chang, Joon; Park, Moo Suk.
In: Tuberculosis and Respiratory Diseases, Vol. 73, No. 6, 01.12.2012, p. 320-324.Research output: Contribution to journal › Article
TY - JOUR
T1 - Sarcoidosis presenting with massive pleural effusion and elevated serum and pleural fluid carbohydrate antigen-125 levels
AU - Lee, In Seon
AU - Kim, Sae Byul
AU - Moon, Chan Soo
AU - Jung, Sung Mo
AU - Kim, Song Yee
AU - Kim, Eun Young
AU - Jung, Ji Ye
AU - kang, youngae
AU - Kim, Young Sam
AU - Kim, Se Kyu
AU - Chang, Joon
AU - Park, Moo Suk
PY - 2012/12/1
Y1 - 2012/12/1
N2 - A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized. Copyright
AB - A 55-year-old woman was admitted for an elevated serum carbohydrate antigen-125 (CA-125) level, and a left pleural effusion, which were detected at a routine health examination. Computed tomography of the chest was performed upon admission, revealing extensive bilateral paratracheal and mediastinal lymph node enlargement with a massive left-sided pleural effusion. Subsequent analysis of the pleural fluid demonstrated consistency with an exudate, no evidence of malignant cells, and a normal adenosine deaminase. However, the pleural fluid and serum CA-125 levels were 2,846.8 U/mL and 229.5 U/mL, respectively. A positron emission tomography did not reveal any primary focus of malignancy. Finally, a surgical mediastinoscopic biopsy of several mediastinal lymph nodes was performed, revealing non-necrotizing granulomas, consistent with sarcoidosis. After a month of treatment of prednisolone, the left pleural effusion had resolved, and after 2 months the serum CA-125 level was normalized. Copyright
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UR - http://www.scopus.com/inward/citedby.url?scp=84872719430&partnerID=8YFLogxK
U2 - 10.4046/trd.2012.73.6.320
DO - 10.4046/trd.2012.73.6.320
M3 - Article
VL - 73
SP - 320
EP - 324
JO - Tuberculosis and Respiratory Diseases
JF - Tuberculosis and Respiratory Diseases
SN - 1738-3536
IS - 6
ER -