Scalp micro-pigmentation via transcutaneous implantation of flexible tissue interlocking biodegradable microneedles

Shayan Fakhraei Lahiji, Daniel Junmin Um, Youseong Kim, Jeesu Jang, Huisuk Yang, Hyungil Jung

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Alopecia, characterized by hair follicle blockage and hair loss, disrupts the normal cycle of hair growth. Although not a life-threatening condition, a growing body of evidence suggests that the psychological state of individuals experiencing alopecia can be highly influenced. Despite considerable research on hair loss treatment, interest in micro-pigmentation has increased in recent decades. Micro-pigmentation is an effective method to camouflage the visual contrast between the scalp and hair strands. However, the localization, intensity and dimension of microdots depend highly upon the physician performing the implantation. Incorrectly localized microdots within the skin may lead to patchy or faded micro-pigmentation. To overcome the limitations of conventional micro-pigmentation, we aimed to develop micro-pigment-encapsulated biodegradable microneedles (PBMs), capable of accurately implanting pigments below the epithelial-dermal junction of the scalp in a minimally invasive manner. A tissue interlocking microneedle technique was utilized to fabricate double-layered PBMs over a biodegradable flexible sheet, which could be washed off post-implantation. We confirmed that the intensity, dimension and insertion depth of 1000 µm-long PBMs was maintained on pig cadaver skin over time. This study suggested that the developed PBMs would serve as an attractive platform for scalp micro-pigmentation in the future.

Original languageEnglish
Article number549
JournalPharmaceutics
Volume11
Issue number11
DOIs
Publication statusPublished - 2019 Nov

Bibliographical note

Funding Information:
Funding: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (grant number: 2019R1A2C1088138), and by the Industrial Core Technology Development Program (2000462, Development of an anti-aging beauty care system using multi active and controlled releasing transdermal delivery for skin layer specific effects), funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea).

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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