Scattered psammomatous calcifications around papillary Thyroid carcinoma

Yong Sang Lee, Soon Won Hong, Hang-Seok Chang, Cheong Soo Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. Objective: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. Materials and methods: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. Results: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. Conclusions: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.

Original languageEnglish
Pages (from-to)1738-1742
Number of pages5
JournalWorld Journal of Surgery
Volume38
Issue number7
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Autoimmune Thyroiditis
Thyroidectomy
Papillary Thyroid cancer
Capsules
Neoplasms
Lymph Nodes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Lee, Yong Sang ; Hong, Soon Won ; Chang, Hang-Seok ; Park, Cheong Soo. / Scattered psammomatous calcifications around papillary Thyroid carcinoma. In: World Journal of Surgery. 2014 ; Vol. 38, No. 7. pp. 1738-1742.
@article{eff17e65999b49ffa7f831449f98b81e,
title = "Scattered psammomatous calcifications around papillary Thyroid carcinoma",
abstract = "Background: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. Objective: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. Materials and methods: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. Results: Scattered psammomatous calcifications around PTC were found in 209 patients (38 {\%}), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. Conclusions: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.",
author = "Lee, {Yong Sang} and Hong, {Soon Won} and Hang-Seok Chang and Park, {Cheong Soo}",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/s00268-014-2460-z",
language = "English",
volume = "38",
pages = "1738--1742",
journal = "World Journal of Surgery",
issn = "0364-2313",
publisher = "Springer New York",
number = "7",

}

Scattered psammomatous calcifications around papillary Thyroid carcinoma. / Lee, Yong Sang; Hong, Soon Won; Chang, Hang-Seok; Park, Cheong Soo.

In: World Journal of Surgery, Vol. 38, No. 7, 01.01.2014, p. 1738-1742.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Scattered psammomatous calcifications around papillary Thyroid carcinoma

AU - Lee, Yong Sang

AU - Hong, Soon Won

AU - Chang, Hang-Seok

AU - Park, Cheong Soo

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. Objective: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. Materials and methods: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. Results: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. Conclusions: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.

AB - Background: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. Objective: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. Materials and methods: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. Results: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. Conclusions: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.

UR - http://www.scopus.com/inward/record.url?scp=84905080450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905080450&partnerID=8YFLogxK

U2 - 10.1007/s00268-014-2460-z

DO - 10.1007/s00268-014-2460-z

M3 - Article

C2 - 24496808

AN - SCOPUS:84905080450

VL - 38

SP - 1738

EP - 1742

JO - World Journal of Surgery

JF - World Journal of Surgery

SN - 0364-2313

IS - 7

ER -