Abstract
Background: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. Objective: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. Materials and methods: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. Results: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. Conclusions: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.
| Original language | English |
|---|---|
| Pages (from-to) | 1738-1742 |
| Number of pages | 5 |
| Journal | World Journal of Surgery |
| Volume | 38 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
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Scattered psammomatous calcifications around papillary Thyroid carcinoma. / Lee, Yong Sang; Hong, Soon Won; Chang, Hang-Seok; Park, Cheong Soo.
In: World Journal of Surgery, Vol. 38, No. 7, 01.01.2014, p. 1738-1742.Research output: Contribution to journal › Article
TY - JOUR
T1 - Scattered psammomatous calcifications around papillary Thyroid carcinoma
AU - Lee, Yong Sang
AU - Hong, Soon Won
AU - Chang, Hang-Seok
AU - Park, Cheong Soo
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. Objective: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. Materials and methods: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. Results: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. Conclusions: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.
AB - Background: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. Objective: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. Materials and methods: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. Results: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. Conclusions: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.
UR - http://www.scopus.com/inward/record.url?scp=84905080450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905080450&partnerID=8YFLogxK
U2 - 10.1007/s00268-014-2460-z
DO - 10.1007/s00268-014-2460-z
M3 - Article
C2 - 24496808
AN - SCOPUS:84905080450
VL - 38
SP - 1738
EP - 1742
JO - World Journal of Surgery
JF - World Journal of Surgery
SN - 0364-2313
IS - 7
ER -