Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma

Chaeyeong Kim; Gyeyeong Kong; Hyunji Lee; Quangdon Tran; Thuy Trang T. Vo; So Hee Kwon; Jisoo Park; Seon Hwan Kim; Jongsun Park

doi:10.1007/s43188-022-00125-5

Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma

Chaeyeong Kim, Gyeyeong Kong, Hyunji Lee, Quangdon Tran, Thuy Trang T. Vo, So Hee Kwon, Jisoo Park, Seon Hwan Kim, Jongsun Park

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

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Abstract

Scavenger receptor class F member 2 (SCARF2) is expressed by endothelial cells with very large cytoplasmic domains and is the second isotype, also known as scavenger receptor expressed by endothelial cells 2 (SREC-2). SREC-1 plays an important role in the binding and endocytosis of various endogenous and exogenous ligands. Many studies have been carried out on modified low-density lipoprotein internalization activity, but there have been few studies on SCARF2. Higher expression of SCARF2 has been found in glioblastoma (GBM) than normal brain tissue. Through analysis of The Cancer Genome Atlas database, it was confirmed that SCARF2 is widely expressed in GBM, and increased SCARF2 expression correlated with a poor prognosis in patients with glioma. The results of this study showed that the expression of SCARF2 is increased in GBM cell lines and patients, suggesting that SCARF2 may be a potential diagnostic marker and therapeutic molecule for cancers including glioma.

Original language	English
Pages (from-to)	249-256
Number of pages	8
Journal	Toxicological Research
Volume	38
Issue number	2
DOIs	https://doi.org/10.1007/s43188-022-00125-5
Publication status	Published - 2022 Apr

Bibliographical note

Funding Information:
This study is funded by National Research Foundation of Korea, NRF-2021R1A2C1008492, NRF-2020R1F1A1049801, NRF-2021R1C1C200845611.

Funding Information:
This work was financially supported by a research scholarship of Chungnam National University (2019) and by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (NRF-2021R1A2C1008492, NRF-2020R1F1A1049801, NRF-2021R1C1C200845611). The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/m9vAFm .

Publisher Copyright:
© 2022, The Author(s) under exclusive licence to Korean Society of Toxicology.

All Science Journal Classification (ASJC) codes

Toxicology
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s43188-022-00125-5

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title = "Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma",

abstract = "Scavenger receptor class F member 2 (SCARF2) is expressed by endothelial cells with very large cytoplasmic domains and is the second isotype, also known as scavenger receptor expressed by endothelial cells 2 (SREC-2). SREC-1 plays an important role in the binding and endocytosis of various endogenous and exogenous ligands. Many studies have been carried out on modified low-density lipoprotein internalization activity, but there have been few studies on SCARF2. Higher expression of SCARF2 has been found in glioblastoma (GBM) than normal brain tissue. Through analysis of The Cancer Genome Atlas database, it was confirmed that SCARF2 is widely expressed in GBM, and increased SCARF2 expression correlated with a poor prognosis in patients with glioma. The results of this study showed that the expression of SCARF2 is increased in GBM cell lines and patients, suggesting that SCARF2 may be a potential diagnostic marker and therapeutic molecule for cancers including glioma.",

author = "Chaeyeong Kim and Gyeyeong Kong and Hyunji Lee and Quangdon Tran and Vo, {Thuy Trang T.} and Kwon, {So Hee} and Jisoo Park and Kim, {Seon Hwan} and Jongsun Park",

note = "Funding Information: This study is funded by National Research Foundation of Korea, NRF-2021R1A2C1008492, NRF-2020R1F1A1049801, NRF-2021R1C1C200845611. Funding Information: This work was financially supported by a research scholarship of Chungnam National University (2019) and by the National Research Foundation of Korea (NRF) grant funded by the Korea Government (MEST) (NRF-2021R1A2C1008492, NRF-2020R1F1A1049801, NRF-2021R1C1C200845611). The English in this document has been checked by at least two professional editors, both native speakers of English. For a certificate, please see: http://www.textcheck.com/certificate/m9vAFm . Publisher Copyright: {\textcopyright} 2022, The Author(s) under exclusive licence to Korean Society of Toxicology.",

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doi = "10.1007/s43188-022-00125-5",

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AU - Kim, Chaeyeong

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AU - Park, Jisoo

AU - Kim, Seon Hwan

AU - Park, Jongsun

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PY - 2022/4

Y1 - 2022/4

N2 - Scavenger receptor class F member 2 (SCARF2) is expressed by endothelial cells with very large cytoplasmic domains and is the second isotype, also known as scavenger receptor expressed by endothelial cells 2 (SREC-2). SREC-1 plays an important role in the binding and endocytosis of various endogenous and exogenous ligands. Many studies have been carried out on modified low-density lipoprotein internalization activity, but there have been few studies on SCARF2. Higher expression of SCARF2 has been found in glioblastoma (GBM) than normal brain tissue. Through analysis of The Cancer Genome Atlas database, it was confirmed that SCARF2 is widely expressed in GBM, and increased SCARF2 expression correlated with a poor prognosis in patients with glioma. The results of this study showed that the expression of SCARF2 is increased in GBM cell lines and patients, suggesting that SCARF2 may be a potential diagnostic marker and therapeutic molecule for cancers including glioma.

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Scavenger receptor class F member 2 (SCARF2) as a novel therapeutic target in glioblastoma

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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