Screening of Thai medicinal plants for anticandidal activity

Yaya Rukayadi, Jae Seok Shim, Jae Kwan Hwang

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Medicinal plants are often used in the treatment of various ailments. In this study, 23 of Thai medicinal plants were screened for their anticandidal activity against six pathogenic Candida species: C. albicans, C. glabrata, C. guilliermondii, C. krusei, C. parapsilosis and C. tropicalis. The methanol extract of Hibiscus sabdariffa L. fruit, Trigonostemon reidioides (Kurz) Craib root, Usnea siamensis Vain whole plant, Boesenbergia rotunda (L.) Mansf. rhizome, and Albizia myriophylla Benth. stem showed anticandidal activity against one or more species of Candida. Among them, A. myriophylla Benth. showed broad anticandidal activity. The susceptibility tests of A. myriophylla Benth. extract, in terms of minimal inhibitory concentrations (MIC) and minimal fungicidal concentration (MFC), were performed by the broth microdilution techniques as described by the Clinical Laboratory Standard Institute. MICs of A. myriophylla Benth. extract to all Candida species was ranged 100-500 μg ml-1. The killing activity of A. myriophylla Benth. extract was fast acting against all Candida tested; the reduction in the number of CFU ml -1 was >3 log10 units (99.9%) in 2 h. This study indicates that A. myriophylla Benth. extract has considerable anticandidal activity, deserving further investigation for clinical applications for the treatment of candidiasis.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalMycoses
Volume51
Issue number4
DOIs
Publication statusPublished - 2008 Jul 1

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Screening of Thai medicinal plants for anticandidal activity'. Together they form a unique fingerprint.

  • Cite this