Second primary brain tumors following cranial irradiation for pediatric solid brain tumors

Sei Hwan You, Chuhl Joo Lyu, Dong Seok Kim, Chang-Ok Suh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: We describe our institution's experience with seven patients who developed second brain tumors following cranial irradiation. Methods: The median age at first irradiation was 8 years (range, 3-20 years). Initial diagnoses were two cases of germinoma, one non-germinomatous germ cell tumor (NGGCT), three cases of medulloblastoma, and one pineal gland tumor (pathology undetermined). All patients received craniospinal irradiation followed by local boost and the median dose to the initial tumor area was 54.0 Gy (range, 49.8-60.6 Gy). Four patients (two medulloblastomas, one germinoma, and one NGGCT) received chemotherapy. Results: Second brain tumors were diagnosed a median of 114 months (range, 64-203) after initial radiation. Pathologic diagnoses were one glioblastoma, two cases of anaplastic astrocytoma, one medulloblastoma, one low-grade glioma, one high-grade glial tumor, and one atypical meningioma. Five patients underwent surgical resection with subsequent radiotherapy. One anaplastic astrocytoma patient received chemotherapy only following stereotactic biopsy. The meningioma patient was alive 32 months after total resection and radiosurgery for subsequent recurrences. Six patients died within 18 months and most deaths were due to disease progression. Conclusions: Most patients diagnosed with second brain tumors had received high-dose, large-volume radiotherapy with chemotherapy at a young age. Further studies are required to determine the relationship between radiotherapy/chemotherapy and the development of secondary brain tumors.

Original languageEnglish
Pages (from-to)1865-1870
Number of pages6
JournalChild's Nervous System
Volume29
Issue number10
DOIs
Publication statusPublished - 2013 Oct 1

Fingerprint

Cranial Irradiation
Brain Neoplasms
Pediatrics
Medulloblastoma
Germinoma
Drug Therapy
Radiotherapy
Germ Cell and Embryonal Neoplasms
Astrocytoma
Meningioma
Craniospinal Irradiation
Pinealoma
Radiosurgery
Glioblastoma
Glioma
Neuroglia
Disease Progression
Neoplasms
Radiation
Pathology

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

You, Sei Hwan ; Lyu, Chuhl Joo ; Kim, Dong Seok ; Suh, Chang-Ok. / Second primary brain tumors following cranial irradiation for pediatric solid brain tumors. In: Child's Nervous System. 2013 ; Vol. 29, No. 10. pp. 1865-1870.
@article{416026fcca7c4051a7c7eb030e26551c,
title = "Second primary brain tumors following cranial irradiation for pediatric solid brain tumors",
abstract = "Purpose: We describe our institution's experience with seven patients who developed second brain tumors following cranial irradiation. Methods: The median age at first irradiation was 8 years (range, 3-20 years). Initial diagnoses were two cases of germinoma, one non-germinomatous germ cell tumor (NGGCT), three cases of medulloblastoma, and one pineal gland tumor (pathology undetermined). All patients received craniospinal irradiation followed by local boost and the median dose to the initial tumor area was 54.0 Gy (range, 49.8-60.6 Gy). Four patients (two medulloblastomas, one germinoma, and one NGGCT) received chemotherapy. Results: Second brain tumors were diagnosed a median of 114 months (range, 64-203) after initial radiation. Pathologic diagnoses were one glioblastoma, two cases of anaplastic astrocytoma, one medulloblastoma, one low-grade glioma, one high-grade glial tumor, and one atypical meningioma. Five patients underwent surgical resection with subsequent radiotherapy. One anaplastic astrocytoma patient received chemotherapy only following stereotactic biopsy. The meningioma patient was alive 32 months after total resection and radiosurgery for subsequent recurrences. Six patients died within 18 months and most deaths were due to disease progression. Conclusions: Most patients diagnosed with second brain tumors had received high-dose, large-volume radiotherapy with chemotherapy at a young age. Further studies are required to determine the relationship between radiotherapy/chemotherapy and the development of secondary brain tumors.",
author = "You, {Sei Hwan} and Lyu, {Chuhl Joo} and Kim, {Dong Seok} and Chang-Ok Suh",
year = "2013",
month = "10",
day = "1",
doi = "10.1007/s00381-013-2098-4",
language = "English",
volume = "29",
pages = "1865--1870",
journal = "Child's Nervous System",
issn = "0256-7040",
publisher = "Springer Verlag",
number = "10",

}

Second primary brain tumors following cranial irradiation for pediatric solid brain tumors. / You, Sei Hwan; Lyu, Chuhl Joo; Kim, Dong Seok; Suh, Chang-Ok.

In: Child's Nervous System, Vol. 29, No. 10, 01.10.2013, p. 1865-1870.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Second primary brain tumors following cranial irradiation for pediatric solid brain tumors

AU - You, Sei Hwan

AU - Lyu, Chuhl Joo

AU - Kim, Dong Seok

AU - Suh, Chang-Ok

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Purpose: We describe our institution's experience with seven patients who developed second brain tumors following cranial irradiation. Methods: The median age at first irradiation was 8 years (range, 3-20 years). Initial diagnoses were two cases of germinoma, one non-germinomatous germ cell tumor (NGGCT), three cases of medulloblastoma, and one pineal gland tumor (pathology undetermined). All patients received craniospinal irradiation followed by local boost and the median dose to the initial tumor area was 54.0 Gy (range, 49.8-60.6 Gy). Four patients (two medulloblastomas, one germinoma, and one NGGCT) received chemotherapy. Results: Second brain tumors were diagnosed a median of 114 months (range, 64-203) after initial radiation. Pathologic diagnoses were one glioblastoma, two cases of anaplastic astrocytoma, one medulloblastoma, one low-grade glioma, one high-grade glial tumor, and one atypical meningioma. Five patients underwent surgical resection with subsequent radiotherapy. One anaplastic astrocytoma patient received chemotherapy only following stereotactic biopsy. The meningioma patient was alive 32 months after total resection and radiosurgery for subsequent recurrences. Six patients died within 18 months and most deaths were due to disease progression. Conclusions: Most patients diagnosed with second brain tumors had received high-dose, large-volume radiotherapy with chemotherapy at a young age. Further studies are required to determine the relationship between radiotherapy/chemotherapy and the development of secondary brain tumors.

AB - Purpose: We describe our institution's experience with seven patients who developed second brain tumors following cranial irradiation. Methods: The median age at first irradiation was 8 years (range, 3-20 years). Initial diagnoses were two cases of germinoma, one non-germinomatous germ cell tumor (NGGCT), three cases of medulloblastoma, and one pineal gland tumor (pathology undetermined). All patients received craniospinal irradiation followed by local boost and the median dose to the initial tumor area was 54.0 Gy (range, 49.8-60.6 Gy). Four patients (two medulloblastomas, one germinoma, and one NGGCT) received chemotherapy. Results: Second brain tumors were diagnosed a median of 114 months (range, 64-203) after initial radiation. Pathologic diagnoses were one glioblastoma, two cases of anaplastic astrocytoma, one medulloblastoma, one low-grade glioma, one high-grade glial tumor, and one atypical meningioma. Five patients underwent surgical resection with subsequent radiotherapy. One anaplastic astrocytoma patient received chemotherapy only following stereotactic biopsy. The meningioma patient was alive 32 months after total resection and radiosurgery for subsequent recurrences. Six patients died within 18 months and most deaths were due to disease progression. Conclusions: Most patients diagnosed with second brain tumors had received high-dose, large-volume radiotherapy with chemotherapy at a young age. Further studies are required to determine the relationship between radiotherapy/chemotherapy and the development of secondary brain tumors.

UR - http://www.scopus.com/inward/record.url?scp=84884356716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884356716&partnerID=8YFLogxK

U2 - 10.1007/s00381-013-2098-4

DO - 10.1007/s00381-013-2098-4

M3 - Article

VL - 29

SP - 1865

EP - 1870

JO - Child's Nervous System

JF - Child's Nervous System

SN - 0256-7040

IS - 10

ER -