Secondary focal segmental glomerulosclerosis: From podocyte injury to glomerulosclerosis

Jae Seok Kim, Byoung Geun Han, Seung Ok Choi, Seung Kuy Cha

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseases progress to ESRD thorough the form of secondary FSGS. The defining feature of FSGS is proteinuria. The key event of FSGS is podocyte injury which is caused by multiple factors. Unanswered questions about how these factors act on podocytes to cause secondary FSGS are various and ill-defined. In this review, we provide brief overview and new insights into FSGS, podocyte injury, and their potential linkage suggesting clues to answer for treatment of the disease.

Original languageEnglish
Article number1630365
JournalBioMed Research International
Volume2016
DOIs
Publication statusPublished - 2016 Jan 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this