Background and objectivesActive smoking is associatedwith higher risk of various diseases.However, the risk of CKD development in nonsmokers exposed to secondhand smoke is notwell elucidated. We aimed to investigate the association between secondhand smoke exposure and the risk of CKD development among never-smokers. Design, setting, participants,& measurementsAtotal of 131,196 never-smokers with normal kidney function,who participated in the Korean Genome and Epidemiology Study from2001 to 2014,were analyzed. The participants were classified into three groups on the basis of frequency of secondhand smoke exposure, assessed with survey questionnaires; no exposure, <3 days perweek, and ≥3 days per week. The association between secondhand smoke and CKD, defined as eGFR<60 ml/min per 1.73 m2, was examined in the cross-sectional analysis. In addition, the risk of incidentCKDdevelopmentwas analyzedin a longitudinal cohort of 1948 participantswithout CKD at baseline, which was a subset of the main cohort. Results The mean age of participants was 53 years, and 75% were women. Prevalent CKD was observed in 231 (1.8%), 64 (1.7%), and 2280 (2.0%) participants in the ≥3 days per week, <3 days per week, and no exposure groups. The odds ratio (OR) of prevalent CKD was significantly higher in the groups exposed to secondhand smoke than the no exposure group (<3 days per week:OR, 1.72; 95% confidence interval [95% CI], 1.30 to 2.27; and≥3 days perweek:OR, 1.44; 95%CI, 1.22 to 1.70). During amean follow-up of 104 months,CKDoccurred in 319 (16%) participants. Multivariable Cox analysis revealed that the risk for CKD development was higher in participants exposed to secondhand smoke than the no exposure group (<3 days perweek: hazard ratio, 1.59; 95% CI, 0.96 to 2.65; and ≥3 days per week: hazard ratio, 1.66; 95% CI, 1.03 to 2.67). Conclusions Exposure to secondhand smoke was associated with a higher prevalence of CKD as well as development of incident CKD.
|Number of pages||8|
|Journal||Clinical Journal of the American Society of Nephrology|
|Publication status||Published - 2019 Apr 5|
Bibliographical noteFunding Information:
The epidemiologic data used in this studywere obtained from the KoreanGenome and Epidemiology Study (KoGES, 4851-302) of the Korea Centers for Disease Control and Prevention, Republic of Korea. This research was supported by a grant from the Ministry for Health and Welfare, Republic of Korea. This study was also supported by a research grant from Inha University Hospital. The funding source had no role in the conception of the study or the collection, analysis, and interpretation of the data,writing of the manuscript, or the decision to submit for publication.
This research was supported by a grant from the Ministry for Health and Welfare, Republic of Korea. This study was also supported by a research grant from Inha University Hospital.
© 2019 by the American Society of Nephrology.
All Science Journal Classification (ASJC) codes
- Critical Care and Intensive Care Medicine