Secondhand smoke and CKD

Jong Hyun Jhee, Young Su Joo, Youn Kyung Kee, Su Young Jung, Seohyun Park, Chang Yun Yoon, Seung Hyeok Han, Tae Hyun Yoo, Shin Wook Kang, Jung Tak Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and objectivesActive smoking is associatedwith higher risk of various diseases.However, the risk of CKD development in nonsmokers exposed to secondhand smoke is notwell elucidated. We aimed to investigate the association between secondhand smoke exposure and the risk of CKD development among never-smokers. Design, setting, participants,& measurementsAtotal of 131,196 never-smokers with normal kidney function,who participated in the Korean Genome and Epidemiology Study from2001 to 2014,were analyzed. The participants were classified into three groups on the basis of frequency of secondhand smoke exposure, assessed with survey questionnaires; no exposure, <3 days perweek, and ≥3 days per week. The association between secondhand smoke and CKD, defined as eGFR<60 ml/min per 1.73 m2, was examined in the cross-sectional analysis. In addition, the risk of incidentCKDdevelopmentwas analyzedin a longitudinal cohort of 1948 participantswithout CKD at baseline, which was a subset of the main cohort. Results The mean age of participants was 53 years, and 75% were women. Prevalent CKD was observed in 231 (1.8%), 64 (1.7%), and 2280 (2.0%) participants in the ≥3 days per week, <3 days per week, and no exposure groups. The odds ratio (OR) of prevalent CKD was significantly higher in the groups exposed to secondhand smoke than the no exposure group (<3 days per week:OR, 1.72; 95% confidence interval [95% CI], 1.30 to 2.27; and≥3 days perweek:OR, 1.44; 95%CI, 1.22 to 1.70). During amean follow-up of 104 months,CKDoccurred in 319 (16%) participants. Multivariable Cox analysis revealed that the risk for CKD development was higher in participants exposed to secondhand smoke than the no exposure group (<3 days perweek: hazard ratio, 1.59; 95% CI, 0.96 to 2.65; and ≥3 days per week: hazard ratio, 1.66; 95% CI, 1.03 to 2.67). Conclusions Exposure to secondhand smoke was associated with a higher prevalence of CKD as well as development of incident CKD.

Original languageEnglish
Pages (from-to)515-522
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Volume14
Issue number4
DOIs
Publication statusPublished - 2019 Apr 5

Fingerprint

Tobacco Smoke Pollution
Odds Ratio
Confidence Intervals
Epidemiology
Cross-Sectional Studies
Smoking
Genome
Kidney

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

Cite this

Jhee, J. H., Joo, Y. S., Kee, Y. K., Jung, S. Y., Park, S., Yoon, C. Y., ... Park, J. T. (2019). Secondhand smoke and CKD. Clinical Journal of the American Society of Nephrology, 14(4), 515-522. https://doi.org/10.2215/CJN.09540818
Jhee, Jong Hyun ; Joo, Young Su ; Kee, Youn Kyung ; Jung, Su Young ; Park, Seohyun ; Yoon, Chang Yun ; Han, Seung Hyeok ; Yoo, Tae Hyun ; Kang, Shin Wook ; Park, Jung Tak. / Secondhand smoke and CKD. In: Clinical Journal of the American Society of Nephrology. 2019 ; Vol. 14, No. 4. pp. 515-522.
@article{27cebc8a99b6475f8dc554297562603d,
title = "Secondhand smoke and CKD",
abstract = "Background and objectivesActive smoking is associatedwith higher risk of various diseases.However, the risk of CKD development in nonsmokers exposed to secondhand smoke is notwell elucidated. We aimed to investigate the association between secondhand smoke exposure and the risk of CKD development among never-smokers. Design, setting, participants,& measurementsAtotal of 131,196 never-smokers with normal kidney function,who participated in the Korean Genome and Epidemiology Study from2001 to 2014,were analyzed. The participants were classified into three groups on the basis of frequency of secondhand smoke exposure, assessed with survey questionnaires; no exposure, <3 days perweek, and ≥3 days per week. The association between secondhand smoke and CKD, defined as eGFR<60 ml/min per 1.73 m2, was examined in the cross-sectional analysis. In addition, the risk of incidentCKDdevelopmentwas analyzedin a longitudinal cohort of 1948 participantswithout CKD at baseline, which was a subset of the main cohort. Results The mean age of participants was 53 years, and 75{\%} were women. Prevalent CKD was observed in 231 (1.8{\%}), 64 (1.7{\%}), and 2280 (2.0{\%}) participants in the ≥3 days per week, <3 days per week, and no exposure groups. The odds ratio (OR) of prevalent CKD was significantly higher in the groups exposed to secondhand smoke than the no exposure group (<3 days per week:OR, 1.72; 95{\%} confidence interval [95{\%} CI], 1.30 to 2.27; and≥3 days perweek:OR, 1.44; 95{\%}CI, 1.22 to 1.70). During amean follow-up of 104 months,CKDoccurred in 319 (16{\%}) participants. Multivariable Cox analysis revealed that the risk for CKD development was higher in participants exposed to secondhand smoke than the no exposure group (<3 days perweek: hazard ratio, 1.59; 95{\%} CI, 0.96 to 2.65; and ≥3 days per week: hazard ratio, 1.66; 95{\%} CI, 1.03 to 2.67). Conclusions Exposure to secondhand smoke was associated with a higher prevalence of CKD as well as development of incident CKD.",
author = "Jhee, {Jong Hyun} and Joo, {Young Su} and Kee, {Youn Kyung} and Jung, {Su Young} and Seohyun Park and Yoon, {Chang Yun} and Han, {Seung Hyeok} and Yoo, {Tae Hyun} and Kang, {Shin Wook} and Park, {Jung Tak}",
year = "2019",
month = "4",
day = "5",
doi = "10.2215/CJN.09540818",
language = "English",
volume = "14",
pages = "515--522",
journal = "Clinical journal of the American Society of Nephrology : CJASN",
issn = "1555-9041",
publisher = "American Society of Nephrology",
number = "4",

}

Jhee, JH, Joo, YS, Kee, YK, Jung, SY, Park, S, Yoon, CY, Han, SH, Yoo, TH, Kang, SW & Park, JT 2019, 'Secondhand smoke and CKD', Clinical Journal of the American Society of Nephrology, vol. 14, no. 4, pp. 515-522. https://doi.org/10.2215/CJN.09540818

Secondhand smoke and CKD. / Jhee, Jong Hyun; Joo, Young Su; Kee, Youn Kyung; Jung, Su Young; Park, Seohyun; Yoon, Chang Yun; Han, Seung Hyeok; Yoo, Tae Hyun; Kang, Shin Wook; Park, Jung Tak.

In: Clinical Journal of the American Society of Nephrology, Vol. 14, No. 4, 05.04.2019, p. 515-522.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Secondhand smoke and CKD

AU - Jhee, Jong Hyun

AU - Joo, Young Su

AU - Kee, Youn Kyung

AU - Jung, Su Young

AU - Park, Seohyun

AU - Yoon, Chang Yun

AU - Han, Seung Hyeok

AU - Yoo, Tae Hyun

AU - Kang, Shin Wook

AU - Park, Jung Tak

PY - 2019/4/5

Y1 - 2019/4/5

N2 - Background and objectivesActive smoking is associatedwith higher risk of various diseases.However, the risk of CKD development in nonsmokers exposed to secondhand smoke is notwell elucidated. We aimed to investigate the association between secondhand smoke exposure and the risk of CKD development among never-smokers. Design, setting, participants,& measurementsAtotal of 131,196 never-smokers with normal kidney function,who participated in the Korean Genome and Epidemiology Study from2001 to 2014,were analyzed. The participants were classified into three groups on the basis of frequency of secondhand smoke exposure, assessed with survey questionnaires; no exposure, <3 days perweek, and ≥3 days per week. The association between secondhand smoke and CKD, defined as eGFR<60 ml/min per 1.73 m2, was examined in the cross-sectional analysis. In addition, the risk of incidentCKDdevelopmentwas analyzedin a longitudinal cohort of 1948 participantswithout CKD at baseline, which was a subset of the main cohort. Results The mean age of participants was 53 years, and 75% were women. Prevalent CKD was observed in 231 (1.8%), 64 (1.7%), and 2280 (2.0%) participants in the ≥3 days per week, <3 days per week, and no exposure groups. The odds ratio (OR) of prevalent CKD was significantly higher in the groups exposed to secondhand smoke than the no exposure group (<3 days per week:OR, 1.72; 95% confidence interval [95% CI], 1.30 to 2.27; and≥3 days perweek:OR, 1.44; 95%CI, 1.22 to 1.70). During amean follow-up of 104 months,CKDoccurred in 319 (16%) participants. Multivariable Cox analysis revealed that the risk for CKD development was higher in participants exposed to secondhand smoke than the no exposure group (<3 days perweek: hazard ratio, 1.59; 95% CI, 0.96 to 2.65; and ≥3 days per week: hazard ratio, 1.66; 95% CI, 1.03 to 2.67). Conclusions Exposure to secondhand smoke was associated with a higher prevalence of CKD as well as development of incident CKD.

AB - Background and objectivesActive smoking is associatedwith higher risk of various diseases.However, the risk of CKD development in nonsmokers exposed to secondhand smoke is notwell elucidated. We aimed to investigate the association between secondhand smoke exposure and the risk of CKD development among never-smokers. Design, setting, participants,& measurementsAtotal of 131,196 never-smokers with normal kidney function,who participated in the Korean Genome and Epidemiology Study from2001 to 2014,were analyzed. The participants were classified into three groups on the basis of frequency of secondhand smoke exposure, assessed with survey questionnaires; no exposure, <3 days perweek, and ≥3 days per week. The association between secondhand smoke and CKD, defined as eGFR<60 ml/min per 1.73 m2, was examined in the cross-sectional analysis. In addition, the risk of incidentCKDdevelopmentwas analyzedin a longitudinal cohort of 1948 participantswithout CKD at baseline, which was a subset of the main cohort. Results The mean age of participants was 53 years, and 75% were women. Prevalent CKD was observed in 231 (1.8%), 64 (1.7%), and 2280 (2.0%) participants in the ≥3 days per week, <3 days per week, and no exposure groups. The odds ratio (OR) of prevalent CKD was significantly higher in the groups exposed to secondhand smoke than the no exposure group (<3 days per week:OR, 1.72; 95% confidence interval [95% CI], 1.30 to 2.27; and≥3 days perweek:OR, 1.44; 95%CI, 1.22 to 1.70). During amean follow-up of 104 months,CKDoccurred in 319 (16%) participants. Multivariable Cox analysis revealed that the risk for CKD development was higher in participants exposed to secondhand smoke than the no exposure group (<3 days perweek: hazard ratio, 1.59; 95% CI, 0.96 to 2.65; and ≥3 days per week: hazard ratio, 1.66; 95% CI, 1.03 to 2.67). Conclusions Exposure to secondhand smoke was associated with a higher prevalence of CKD as well as development of incident CKD.

UR - http://www.scopus.com/inward/record.url?scp=85064501270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064501270&partnerID=8YFLogxK

U2 - 10.2215/CJN.09540818

DO - 10.2215/CJN.09540818

M3 - Article

C2 - 30846462

AN - SCOPUS:85064501270

VL - 14

SP - 515

EP - 522

JO - Clinical journal of the American Society of Nephrology : CJASN

JF - Clinical journal of the American Society of Nephrology : CJASN

SN - 1555-9041

IS - 4

ER -

Jhee JH, Joo YS, Kee YK, Jung SY, Park S, Yoon CY et al. Secondhand smoke and CKD. Clinical Journal of the American Society of Nephrology. 2019 Apr 5;14(4):515-522. https://doi.org/10.2215/CJN.09540818