Sedation methods can determine performance of endoscopic submucosal dissection in patients with gastric neoplasia

Chan Hyuk Park, Jae Hoon Min, Young Chul Yoo, Hyunzu Kim, Dong Hoo Joh, Jung Hyun Jo, Suji Shin, Hyuk Lee, Jun Chul Park, Sung Kwan Shin, Yong Chan Lee, Sang Kil Lee

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Although proper sedation is mandatory for endoscopic procedures such as endoscopic submucosal dissection (ESD), there is no research investigating the effects of sedation on ESD performance and complications. We aimed to evaluate the relationship among sedation methods, clinical outcomes, and complications after ESD for gastric neoplasia. Methods: We retrospectively reviewed clinical data of 1,367 patients with 1,485 lesions who had undergone ESD for gastric adenoma or early gastric cancer at our tertiary teaching hospital in Seoul, Korea, between January 2008 and May 2011. Of these, 1,035 lesions in 958 patients were included in the intermittent midazolam/propofol injection by endoscopists (IMIE) group, and 450 lesions in 409 patients were included in the continuous propofol infusion with opioid administration by anesthesiologists (CPIA) group. Results: En bloc resection and complete resection rates were higher in the CPIA group than in the IMIE group (CPIA vs. IMIE; en bloc resection, 99.8 and 95.0 %, P < 0.001; complete resection, 94.2 and 88.3 %, P < 0.001). Duration of procedure was shorter in the CPIA group than in the IMIE group (CPIA vs. IMIE; 48.2 ± 32.5 and 57.6 ± 41.3 min, P < 0.001). In multivariate analysis, sedation method was an independent factor associated with en bloc resection and complete resection. Additionally, sedation with CPIA was not a risk factor for bleeding (P = 0.403) or perforation (P = 0.474); however, aspiration pneumonia developed more frequently in patients sedated with CPIA (CPIA vs. IMIE, 4.4 and 1.5 %, P = 0.002). Conclusions: Sedation with CPIA can improve ESD performance.

Original languageEnglish
Pages (from-to)2760-2767
Number of pages8
JournalSurgical endoscopy
Volume27
Issue number8
DOIs
Publication statusPublished - 2013 Aug

All Science Journal Classification (ASJC) codes

  • Surgery

Fingerprint Dive into the research topics of 'Sedation methods can determine performance of endoscopic submucosal dissection in patients with gastric neoplasia'. Together they form a unique fingerprint.

  • Cite this

    Park, C. H., Min, J. H., Yoo, Y. C., Kim, H., Joh, D. H., Jo, J. H., Shin, S., Lee, H., Park, J. C., Shin, S. K., Lee, Y. C., & Lee, S. K. (2013). Sedation methods can determine performance of endoscopic submucosal dissection in patients with gastric neoplasia. Surgical endoscopy, 27(8), 2760-2767. https://doi.org/10.1007/s00464-013-2804-z