Seizure outcome of infantile spasms with focal cortical dysplasia

Joon Won Kang, Seon Kyeong Rhie, Rita Yu, Soyong Eom, William Hong, Shin Hye Kim, hoonchul kang, Joon Soo Lee, Young Mock Lee, HeungDong Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: This study sought to evaluate the seizure outcome of infantile spasms (IS) with focal cortical dysplasia (FCD). Methods: We retrospectively reviewed infantile spasms patients with FCD from 2004 to 2010. We investigated seizure outcome from antiepileptic drug (AED), ketogenic diet (KD), resective surgery, and analyzed the results according to individual imaging studies. Results: Among 404 patients of IS, FCD was confirmed in 51 patients. In retrospective review of brain MRI, only 21 patients (41.2%) were suspected of FCD before 1. year of age, but 45 patients (88.2%) became confirmed to FCD by MRI after the age of 1. year. Once the spasms were not controlled by 1 or 2 AEDs, the chance of becoming seizure free with additional third or more drugs was very low (2.3%). The seizure free rate was 33.3% (7/21) in patients treated with ketogenic diet, and 73.3% (22/30) in surgical patients, who were both intractable to AEDs. There were no significant differences in seizure free rate in both ketogenic diet and surgical patients, between MRI negative and positive patients prior to 1. year of age. Conclusions: KD and surgery should be considered in medically refractory IS with FCD.

Original languageEnglish
Pages (from-to)816-820
Number of pages5
JournalBrain and Development
Volume35
Issue number8
DOIs
Publication statusPublished - 2013 Sep 1

Fingerprint

Infantile Spasms
Malformations of Cortical Development
Seizures
Ketogenic Diet
Spasm
Anticonvulsants

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Kang, Joon Won ; Rhie, Seon Kyeong ; Yu, Rita ; Eom, Soyong ; Hong, William ; Kim, Shin Hye ; kang, hoonchul ; Lee, Joon Soo ; Lee, Young Mock ; Kim, HeungDong. / Seizure outcome of infantile spasms with focal cortical dysplasia. In: Brain and Development. 2013 ; Vol. 35, No. 8. pp. 816-820.
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abstract = "Purpose: This study sought to evaluate the seizure outcome of infantile spasms (IS) with focal cortical dysplasia (FCD). Methods: We retrospectively reviewed infantile spasms patients with FCD from 2004 to 2010. We investigated seizure outcome from antiepileptic drug (AED), ketogenic diet (KD), resective surgery, and analyzed the results according to individual imaging studies. Results: Among 404 patients of IS, FCD was confirmed in 51 patients. In retrospective review of brain MRI, only 21 patients (41.2{\%}) were suspected of FCD before 1. year of age, but 45 patients (88.2{\%}) became confirmed to FCD by MRI after the age of 1. year. Once the spasms were not controlled by 1 or 2 AEDs, the chance of becoming seizure free with additional third or more drugs was very low (2.3{\%}). The seizure free rate was 33.3{\%} (7/21) in patients treated with ketogenic diet, and 73.3{\%} (22/30) in surgical patients, who were both intractable to AEDs. There were no significant differences in seizure free rate in both ketogenic diet and surgical patients, between MRI negative and positive patients prior to 1. year of age. Conclusions: KD and surgery should be considered in medically refractory IS with FCD.",
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Kang, JW, Rhie, SK, Yu, R, Eom, S, Hong, W, Kim, SH, kang, H, Lee, JS, Lee, YM & Kim, H 2013, 'Seizure outcome of infantile spasms with focal cortical dysplasia', Brain and Development, vol. 35, no. 8, pp. 816-820. https://doi.org/10.1016/j.braindev.2013.06.013

Seizure outcome of infantile spasms with focal cortical dysplasia. / Kang, Joon Won; Rhie, Seon Kyeong; Yu, Rita; Eom, Soyong; Hong, William; Kim, Shin Hye; kang, hoonchul; Lee, Joon Soo; Lee, Young Mock; Kim, HeungDong.

In: Brain and Development, Vol. 35, No. 8, 01.09.2013, p. 816-820.

Research output: Contribution to journalArticle

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N2 - Purpose: This study sought to evaluate the seizure outcome of infantile spasms (IS) with focal cortical dysplasia (FCD). Methods: We retrospectively reviewed infantile spasms patients with FCD from 2004 to 2010. We investigated seizure outcome from antiepileptic drug (AED), ketogenic diet (KD), resective surgery, and analyzed the results according to individual imaging studies. Results: Among 404 patients of IS, FCD was confirmed in 51 patients. In retrospective review of brain MRI, only 21 patients (41.2%) were suspected of FCD before 1. year of age, but 45 patients (88.2%) became confirmed to FCD by MRI after the age of 1. year. Once the spasms were not controlled by 1 or 2 AEDs, the chance of becoming seizure free with additional third or more drugs was very low (2.3%). The seizure free rate was 33.3% (7/21) in patients treated with ketogenic diet, and 73.3% (22/30) in surgical patients, who were both intractable to AEDs. There were no significant differences in seizure free rate in both ketogenic diet and surgical patients, between MRI negative and positive patients prior to 1. year of age. Conclusions: KD and surgery should be considered in medically refractory IS with FCD.

AB - Purpose: This study sought to evaluate the seizure outcome of infantile spasms (IS) with focal cortical dysplasia (FCD). Methods: We retrospectively reviewed infantile spasms patients with FCD from 2004 to 2010. We investigated seizure outcome from antiepileptic drug (AED), ketogenic diet (KD), resective surgery, and analyzed the results according to individual imaging studies. Results: Among 404 patients of IS, FCD was confirmed in 51 patients. In retrospective review of brain MRI, only 21 patients (41.2%) were suspected of FCD before 1. year of age, but 45 patients (88.2%) became confirmed to FCD by MRI after the age of 1. year. Once the spasms were not controlled by 1 or 2 AEDs, the chance of becoming seizure free with additional third or more drugs was very low (2.3%). The seizure free rate was 33.3% (7/21) in patients treated with ketogenic diet, and 73.3% (22/30) in surgical patients, who were both intractable to AEDs. There were no significant differences in seizure free rate in both ketogenic diet and surgical patients, between MRI negative and positive patients prior to 1. year of age. Conclusions: KD and surgery should be considered in medically refractory IS with FCD.

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