Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Hye Yeon Lee, Yoon Pyo Choi, Sunkyung Kim, Taejin Yoon, Zhiqian Guo, Songyi Lee, K. M.K. Swamy, Gyoungmi Kim, Jin Yong Lee, Injae Shin, Juyoung Yoon

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108 Citations (Scopus)

Abstract

The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.

Original languageEnglish
Pages (from-to)6967-6969
Number of pages3
JournalChemical Communications
Volume50
Issue number53
DOIs
Publication statusPublished - 2014 Jun 3

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Lee, H. Y., Choi, Y. P., Kim, S., Yoon, T., Guo, Z., Lee, S., Swamy, K. M. K., Kim, G., Lee, J. Y., Shin, I., & Yoon, J. (2014). Selective homocysteine turn-on fluorescent probes and their bioimaging applications. Chemical Communications, 50(53), 6967-6969. https://doi.org/10.1039/c4cc00243a