Abstract
The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.
| Original language | English |
|---|---|
| Pages (from-to) | 6967-6969 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 50 |
| Issue number | 53 |
| DOIs | |
| Publication status | Published - 2014 Jul 7 |
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All Science Journal Classification (ASJC) codes
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
Cite this
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Selective homocysteine turn-on fluorescent probes and their bioimaging applications. / Lee, Hye Yeon; Choi, Yoon Pyo; Kim, Sunkyung; Yoon, Taejin; Guo, Zhiqian; Lee, Songyi; Swamy, K. M.K.; Kim, Gyoungmi; Lee, Jin Yong; Shin, Injae; Yoon, Juyoung.
In: Chemical Communications, Vol. 50, No. 53, 07.07.2014, p. 6967-6969.Research output: Contribution to journal › Article
TY - JOUR
T1 - Selective homocysteine turn-on fluorescent probes and their bioimaging applications
AU - Lee, Hye Yeon
AU - Choi, Yoon Pyo
AU - Kim, Sunkyung
AU - Yoon, Taejin
AU - Guo, Zhiqian
AU - Lee, Songyi
AU - Swamy, K. M.K.
AU - Kim, Gyoungmi
AU - Lee, Jin Yong
AU - Shin, Injae
AU - Yoon, Juyoung
PY - 2014/7/7
Y1 - 2014/7/7
N2 - The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.
AB - The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.
UR - http://www.scopus.com/inward/record.url?scp=84902009385&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902009385&partnerID=8YFLogxK
U2 - 10.1039/c4cc00243a
DO - 10.1039/c4cc00243a
M3 - Article
C2 - 24643707
AN - SCOPUS:84902009385
VL - 50
SP - 6967
EP - 6969
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 53
ER -