Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Hye Yeon Lee; Yoon Pyo Choi; Sunkyung Kim; Taejin Yoon; Zhiqian Guo; Songyi Lee; K. M.K. Swamy; Gyoungmi Kim; Jin Yong Lee; Injae Shin; Juyoung Yoon

doi:10.1039/c4cc00243a

Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Hye Yeon Lee, Yoon Pyo Choi, Sunkyung Kim, Taejin Yoon, Zhiqian Guo, Songyi Lee, K. M.K. Swamy, Gyoungmi Kim, Jin Yong Lee, Injae Shin, Juyoung Yoon

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

135 Citations (Scopus)

Abstract

The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.

Original language	English
Pages (from-to)	6967-6969
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	53
DOIs	https://doi.org/10.1039/c4cc00243a
Publication status	Published - 2014 Jun 3

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c4cc00243a

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abstract = "The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.",

author = "Lee, {Hye Yeon} and Choi, {Yoon Pyo} and Sunkyung Kim and Taejin Yoon and Zhiqian Guo and Songyi Lee and Swamy, {K. M.K.} and Gyoungmi Kim and Lee, {Jin Yong} and Injae Shin and Juyoung Yoon",

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doi = "10.1039/c4cc00243a",

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T1 - Selective homocysteine turn-on fluorescent probes and their bioimaging applications

AU - Lee, Hye Yeon

AU - Choi, Yoon Pyo

AU - Kim, Sunkyung

AU - Yoon, Taejin

AU - Guo, Zhiqian

AU - Lee, Songyi

AU - Swamy, K. M.K.

AU - Kim, Gyoungmi

AU - Lee, Jin Yong

AU - Shin, Injae

AU - Yoon, Juyoung

PY - 2014/6/3

Y1 - 2014/6/3

N2 - The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.

AB - The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.

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JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 53

ER -

Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Abstract

All Science Journal Classification (ASJC) codes

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