Selective homocysteine turn-on fluorescent probes and their bioimaging applications

Hye Yeon Lee, Yoon Pyo Choi, Sunkyung Kim, Taejin Yoon, Zhiqian Guo, Songyi Lee, K. M.K. Swamy, Gyoungmi Kim, Jin Yong Lee, Injae Shin, Juyoung Yoon

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.

Original languageEnglish
Pages (from-to)6967-6969
Number of pages3
JournalChemical Communications
Volume50
Issue number53
DOIs
Publication statusPublished - 2014 Jul 7

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Homocysteine
Fluorescent Dyes
Fluorescence
Pyrene
Cells
Experiments

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Lee, H. Y., Choi, Y. P., Kim, S., Yoon, T., Guo, Z., Lee, S., ... Yoon, J. (2014). Selective homocysteine turn-on fluorescent probes and their bioimaging applications. Chemical Communications, 50(53), 6967-6969. https://doi.org/10.1039/c4cc00243a
Lee, Hye Yeon ; Choi, Yoon Pyo ; Kim, Sunkyung ; Yoon, Taejin ; Guo, Zhiqian ; Lee, Songyi ; Swamy, K. M.K. ; Kim, Gyoungmi ; Lee, Jin Yong ; Shin, Injae ; Yoon, Juyoung. / Selective homocysteine turn-on fluorescent probes and their bioimaging applications. In: Chemical Communications. 2014 ; Vol. 50, No. 53. pp. 6967-6969.
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Lee, HY, Choi, YP, Kim, S, Yoon, T, Guo, Z, Lee, S, Swamy, KMK, Kim, G, Lee, JY, Shin, I & Yoon, J 2014, 'Selective homocysteine turn-on fluorescent probes and their bioimaging applications', Chemical Communications, vol. 50, no. 53, pp. 6967-6969. https://doi.org/10.1039/c4cc00243a

Selective homocysteine turn-on fluorescent probes and their bioimaging applications. / Lee, Hye Yeon; Choi, Yoon Pyo; Kim, Sunkyung; Yoon, Taejin; Guo, Zhiqian; Lee, Songyi; Swamy, K. M.K.; Kim, Gyoungmi; Lee, Jin Yong; Shin, Injae; Yoon, Juyoung.

In: Chemical Communications, Vol. 50, No. 53, 07.07.2014, p. 6967-6969.

Research output: Contribution to journalArticle

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AU - Guo, Zhiqian

AU - Lee, Songyi

AU - Swamy, K. M.K.

AU - Kim, Gyoungmi

AU - Lee, Jin Yong

AU - Shin, Injae

AU - Yoon, Juyoung

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