Abstract
The design and development of new pyrene-based fluorescent probes, P-Hcy-1 and P-Hcy-2, which display selective fluorescence enhancements in response to homocysteine (Hcy), are described. The distinctly different fluorescence responses of P-Hcy-1 and P-Hcy-2 to Hcy vs. Cys are explained by theoretical calculations. Finally, the results of cell experiments show that these probes can be used to selectively detect Hcy in mammalian cells.
| Original language | English |
|---|---|
| Pages (from-to) | 6967-6969 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 50 |
| Issue number | 53 |
| DOIs | |
| Publication status | Published - 2014 Jun 3 |
All Science Journal Classification (ASJC) codes
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Cite this
Lee, H. Y., Choi, Y. P., Kim, S., Yoon, T., Guo, Z., Lee, S., Swamy, K. M. K., Kim, G., Lee, J. Y., Shin, I., & Yoon, J. (2014). Selective homocysteine turn-on fluorescent probes and their bioimaging applications. Chemical Communications, 50(53), 6967-6969. https://doi.org/10.1039/c4cc00243a