Self-aligned colocalization of 3D plasmonic nanogap arrays for ultra-sensitive surface plasmon resonance detection

Youngjin Oh, Wonju Lee, Yonghwi Kim, Donghyun Kim

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We report extremely sensitive plasmonic detection that was performed label-free based on the colocalization of target DNA molecules and electromagnetic hot spots excited at 3D nanogap arrays. The colocalization was self-aligned by oblique evaporation of a dielectric mask over the 3D nanopatterns, which creates nanogaps for spatially selective target binding. The feasibility was experimentally confirmed by measuring hybridization of 24-mer single-stranded DNA oligonucleotides on triangular and circular 3D nanogap arrays. We were able to achieve significantly amplified optical signatures that lead to sensitivity enhancement in terms of detectable binding capacity in reference to conventional thin film-based surface plasmon resonance detection on the order of 1fg/mm2.

Original languageEnglish
Pages (from-to)401-407
Number of pages7
JournalBiosensors and Bioelectronics
Volume51
DOIs
Publication statusPublished - 2014 Jan 15

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Surface Plasmon Resonance
Electromagnetic Phenomena
Single-Stranded DNA
Surface plasmon resonance
Masks
Oligonucleotides
Labels
Evaporation
DNA
Thin films
Molecules

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

Cite this

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Self-aligned colocalization of 3D plasmonic nanogap arrays for ultra-sensitive surface plasmon resonance detection. / Oh, Youngjin; Lee, Wonju; Kim, Yonghwi; Kim, Donghyun.

In: Biosensors and Bioelectronics, Vol. 51, 15.01.2014, p. 401-407.

Research output: Contribution to journalArticle

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