Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging

Eun Kyung Lim, Seungjoo Haam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We fabricated multimode nanoprobes for acquisition of biological information at different object levels, i.e., in vivo detection and ex vivo validation for characterizing tumor angiogenesis. Fluorescent magnetic nanoprobes (FMNPs) were synthesized by using amphiphilic pyrenyl polyethylene glycol (Py-PEG) and superparamagnetic MnFe2O4 nanocrystals (MNCs). Py-PEG, which is synthesized by conjugation of hydrophilic PEG with hydrophobic and fluorescent l-pyrenebutyric acid through an esterification process, is capable of self-assembly and maintaining a high UV fluorescent intensity in aqueous phase. Py-PEG can be used as a fluorescent surfactant that simultaneously and efficiently encapsulates MNCs to exhibit fluorescent and magnetic properties as well as maintaining highwater-solubility. Consequently, we proved that our biologically non-toxic FMNPs were prominent multimode imaging probes by showing not only excellent MR sensitivity but also high illumination intensity with strong signal strength under short exposure time of UV light from the extensive imaging studies of in vitro/vivo and ex vivo using orthotopic and xenograft mice models.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages359-362
Number of pages4
Volume1
Publication statusPublished - 2011 Nov 23
EventNanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: 2011 Jun 132011 Jun 16

Other

OtherNanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
CountryUnited States
CityBoston, MA
Period11/6/1311/6/16

Fingerprint

Nanoprobes
Polyethylene glycols
glycols
polyethylenes
Imaging techniques
Nanocrystals
nanocrystals
angiogenesis
Esterification
conjugation
Heterografts
Surface-Active Agents
Ultraviolet radiation
Self assembly
mice
self assembly
Tumors
Magnetic properties
acquisition
tumors

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

Cite this

Lim, E. K., & Haam, S. (2011). Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging. In Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 (Vol. 1, pp. 359-362)
Lim, Eun Kyung ; Haam, Seungjoo. / Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging. Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. Vol. 1 2011. pp. 359-362
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Lim, EK & Haam, S 2011, Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging. in Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. vol. 1, pp. 359-362, Nanotechnology 2011: Advanced Materials, CNTs, Particles, Films and Composites - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011, Boston, MA, United States, 11/6/13.

Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging. / Lim, Eun Kyung; Haam, Seungjoo.

Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. Vol. 1 2011. p. 359-362.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Lim EK, Haam S. Self-assembled fluorescent magnetic nanoprobes for multimode-biomedical imaging. In Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. Vol. 1. 2011. p. 359-362