Self-assembled multivalent carbohydrate ligands

Yong Beom Lim, Myongsoo Lee

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Materials that display multiple carbohydrate residues have gained much attention due to their potential to inhibit or modulate biological multivalent interactions. These materials can be grouped accordingly to the way they are prepared, as unimolecular or as self-assembled systems. Both systems take advantage of the fact that multivalent interactions have significantly higher binding affinity than the corresponding monovalent interactions. The self-assembled system is a more recent field of research compared to the unimolecular system. In this review, we describe current efforts to realize multivalent carbohydrate interactions from the perspective of synthetic self-assembled systems. We limit the scope to self-assembled systems that are stable, soluble in aqueous solution and morphologically discrete. We grouped them into two separate categories. In the first category carbohydrate ligands self-assemble onto a pre-organized nanostructure, and in the second carbohydrate-conjugated block molecules spontaneously assemble to construct morphologically distinct nanostructures.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume5
Issue number3
DOIs
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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