Self-assembling process of flash nanoprecipitation in a multi-inlet vortex mixer to produce drug-loaded polymeric nanoparticles

Hao Shen, Seungpyo Hong, Robert K. Prud'Homme, Ying Liu

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

We present an experimental study of selfassembled polymeric nanoparticles in the process of flash nanoprecipitation using a multi-inlet vortex mixer (MIVM). β-Carotene and polyethyleneimine (PEI) are used as a model drug and a macromolecule, respectively, and encapsulated in diblock copolymers. Flow patterns in the MIVM are microscopically visualized by mixing iron nitrate (Fe(NO3)3) and potassium thiocyanate (KSCN) to precipitate Fe(SCN)(3-x)+x. Effects of physical parameters, including Reynolds number, supersaturation rate, interaction force, and drug-loading rate, on size distribution of the nanoparticle suspensions are investigated. It is critical for the nanoprecipitation process to have a short mixing time, so that the solvent replacement starts homogeneously in the reactor. The properties of the nanoparticles depend on the competitive kinetics of polymer aggregation and organic solute nucleation and growth. We report the existence of a threshold Reynolds number over which nanoparticle sizes become independent of mixing. A similar value of the threshold Reynolds number is confirmed by independent measurements of particle size, flowpattern visualization, and our previous numerical simulation along with experimental study of competitive reactions in the MIVM.

Original languageEnglish
Pages (from-to)4109-4120
Number of pages12
JournalJournal of Nanoparticle Research
Volume13
Issue number9
DOIs
Publication statusPublished - 2011 Sep 1

Fingerprint

Flash
assembling
Nanoparticles
flash
Vortex
Drugs
drugs
Vortex flow
vortices
Reynolds number
nanoparticles
Flow Pattern
Pharmaceutical Preparations
Experimental Study
Polyethyleneimine
carotene
Mixing Time
loading rate
thresholds
Copolymer

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Chemistry(all)
  • Modelling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

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abstract = "We present an experimental study of selfassembled polymeric nanoparticles in the process of flash nanoprecipitation using a multi-inlet vortex mixer (MIVM). β-Carotene and polyethyleneimine (PEI) are used as a model drug and a macromolecule, respectively, and encapsulated in diblock copolymers. Flow patterns in the MIVM are microscopically visualized by mixing iron nitrate (Fe(NO3)3) and potassium thiocyanate (KSCN) to precipitate Fe(SCN)(3-x)+x. Effects of physical parameters, including Reynolds number, supersaturation rate, interaction force, and drug-loading rate, on size distribution of the nanoparticle suspensions are investigated. It is critical for the nanoprecipitation process to have a short mixing time, so that the solvent replacement starts homogeneously in the reactor. The properties of the nanoparticles depend on the competitive kinetics of polymer aggregation and organic solute nucleation and growth. We report the existence of a threshold Reynolds number over which nanoparticle sizes become independent of mixing. A similar value of the threshold Reynolds number is confirmed by independent measurements of particle size, flowpattern visualization, and our previous numerical simulation along with experimental study of competitive reactions in the MIVM.",
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Self-assembling process of flash nanoprecipitation in a multi-inlet vortex mixer to produce drug-loaded polymeric nanoparticles. / Shen, Hao; Hong, Seungpyo; Prud'Homme, Robert K.; Liu, Ying.

In: Journal of Nanoparticle Research, Vol. 13, No. 9, 01.09.2011, p. 4109-4120.

Research output: Contribution to journalArticle

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