Self-fabricated dextran-coated gold nanoparticles using pyrenyl dextran as a reducible stabilizer and their application as CT imaging agents for atherosclerosis

Eun Kyung Lim, Eunji Jang, Jeonghun Kim, Taeksu Lee, Eunkyoung Kim, Hyo Seon Park, Jinsuck Suh, yongmin Huh, Seungjoo Haam

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A facile method to produce dextran-coated gold nanoparticles (DGNPs) for atherosclerosis detection using computed tomography (CT) imaging is developed. DGNPs are prepared using only pyrenyl dextran as a reducible stabilizer chemically conjugated with hydroxyl groups of dextran and carboxyl groups of pyrenyl molecules, which can reduce gold ions to gold particles and stably form gold nanoparticles in the aqueous phase. The physical properties of DGNPs can be controlled by the reaction time. DGNPs, where gold particles were stably covered with dextran, exhibit targeting ability against inflammatory macrophages with the help of strong interactions between dextran on their surface and scavenger receptors in the macrophages with good biocompatibility without cell damage. From the in vivo studies, DGNPs can be used to accurately detect atherosclerosis via CT imaging.

Original languageEnglish
Pages (from-to)17518-17524
Number of pages7
JournalJournal of Materials Chemistry
Volume22
Issue number34
DOIs
Publication statusPublished - 2012 Sep 14

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Stabilizers (agents)
Dextran
Dextrans
Gold
Tomography
Nanoparticles
Imaging techniques
Macrophages
Scavenger Receptors
Biocompatibility
Hydroxyl Radical
Physical properties
Cells
Ions
Molecules

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Chemistry

Cite this

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abstract = "A facile method to produce dextran-coated gold nanoparticles (DGNPs) for atherosclerosis detection using computed tomography (CT) imaging is developed. DGNPs are prepared using only pyrenyl dextran as a reducible stabilizer chemically conjugated with hydroxyl groups of dextran and carboxyl groups of pyrenyl molecules, which can reduce gold ions to gold particles and stably form gold nanoparticles in the aqueous phase. The physical properties of DGNPs can be controlled by the reaction time. DGNPs, where gold particles were stably covered with dextran, exhibit targeting ability against inflammatory macrophages with the help of strong interactions between dextran on their surface and scavenger receptors in the macrophages with good biocompatibility without cell damage. From the in vivo studies, DGNPs can be used to accurately detect atherosclerosis via CT imaging.",
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AU - Lim, Eun Kyung

AU - Jang, Eunji

AU - Kim, Jeonghun

AU - Lee, Taeksu

AU - Kim, Eunkyoung

AU - Park, Hyo Seon

AU - Suh, Jinsuck

AU - Huh, yongmin

AU - Haam, Seungjoo

PY - 2012/9/14

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