Self-navigated interleaved spiral (SNAILS): Application to high-resolution diffusion tensor imaging

Chunlei Liu, Roland Bammer, Dong Hyun Kim, Michael E. Moseley

Research output: Contribution to journalArticlepeer-review

196 Citations (Scopus)


A fat-saturated twice-refocused spin echo sequence was implemented on a GE Signa 1.5-T whole-body system for diffusion-weighted imaging. Data were acquired using an analytically designed interleaved variable-density (VD) spiral readout trajectory. This flexible design algorithm allowed real-time prescription on the scanner. Each interleaf of the VD spiral oversampled the center of k-space. The oversampling provided an inherent motion compensation capability. The resultant diffusion-weighted images showed good quality without any retrospective motion correction. An iterated motion correction algorithm was developed to further reduce the signal cancellation artifact caused by motion-induced phase error. In this algorithm, a low-resolution phase map was estimated using the oversampled data in the center of k-space in order to correct for phase error in image space. In vivo diffusion tensor imaging (DTI) studies were performed on the brains of healthy volunteers. High-quality isotropic diffusion-weighted images, trace maps, and FA maps from axial, sagittal, and coronal slices were obtained using a VD spiral readout trajectory with matrix size 256 × 256. To our knowledge, this was also the first time in vivo 512 × 512 DTI results were reported.

Original languageEnglish
Pages (from-to)1388-1396
Number of pages9
JournalMagnetic Resonance in Medicine
Issue number6
Publication statusPublished - 2004 Dec

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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