Self-Plugging Microneedle (SPM) for Intravitreal Drug Delivery

Kang Ju Lee; Seung Hyun Park; Dong Hyun Jo; Chang Sik Cho; Ha Young Jang; Jiyeon Yi; Minkyung Kang; Jaeho Kim; Ho Yun Jung; Jeong Hun Kim; Won Hyoung Ryu; Ali Khademhosseini

doi:10.1002/adhm.202102599

Self-Plugging Microneedle (SPM) for Intravitreal Drug Delivery

Kang Ju Lee, Seung Hyun Park, Dong Hyun Jo, Chang Sik Cho, Ha Young Jang, Jiyeon Yi, Minkyung Kang, Jaeho Kim, Ho Yun Jung, Jeong Hun Kim, Won Hyoung Ryu, Ali Khademhosseini

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Intravitreal injection (IVI) is a common technology which is used to treat ophthalmic diseases inside eyeballs by delivering various drugs into the vitreous cavity using hypodermic needles. However, in some cases, there are possible side effects such as ocular tissue damage due to repeated injection or eyeball infection through the hole created during the needle retraction process. The best scenario of IVI is a one-time injection of drugs without needle retraction, keeping the system of the eyeball closed. Microneedles (MNs) have been applied to ocular tissues over 10 years, and no serious side effects on ocular tissue due to MN injection have been reported. Therefore, a self-plugging MN (SPM) is developed to perform intraocular drug delivery and to seal the scleral puncture simultaneously. The SPMs are fabricated by a thermal drawing process and then coated with a polymeric carrier of drugs and a hydrogel-based scleral plugging component. Each coated functional layer is characterized and demonstrated by in vitro and ex vivo experiments. Finally, in vivo tests using a porcine model confirms prompt sealing of SPM and sustained intraocular drug delivery.

Original language	English
Article number	2102599
Journal	Advanced Healthcare Materials
Volume	11
Issue number	12
DOIs	https://doi.org/10.1002/adhm.202102599
Publication status	Published - 2022 Jun

Bibliographical note

Funding Information:
K.L., S.P. and D.H.J. contributed equally to this work. This research was supported by a grant of National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2021R1F1A105502211 (K.L.)), a grant of Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (HI18C1237 (W.R.)), Global Infrastructure Program through the NRF funded by the MSIT (2019K1A3A1A18116048, (W.R.)), the Basic Science Research Program through the NRF funded by the Ministry of Education (NRF‐2017R1A6A3A04004741 (D.H.J.)), the Creative Materials Discovery Program through the NRF funded by the Ministry of Science and ICT (2018M3D1A1058826 (J.H.K.)), the Development of Platform Technology for Innovative Medical Measurements funded by Korea Research Institute of Standards and Science (KRISS–2021– GP2021‐ 0004 (J.H.K.)).

Publisher Copyright:
© 2022 Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering
Pharmaceutical Science

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10.1002/adhm.202102599

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@article{4ad38bb78cba405a9085ebcc7361bfca,

title = "Self-Plugging Microneedle (SPM) for Intravitreal Drug Delivery",

abstract = "Intravitreal injection (IVI) is a common technology which is used to treat ophthalmic diseases inside eyeballs by delivering various drugs into the vitreous cavity using hypodermic needles. However, in some cases, there are possible side effects such as ocular tissue damage due to repeated injection or eyeball infection through the hole created during the needle retraction process. The best scenario of IVI is a one-time injection of drugs without needle retraction, keeping the system of the eyeball closed. Microneedles (MNs) have been applied to ocular tissues over 10 years, and no serious side effects on ocular tissue due to MN injection have been reported. Therefore, a self-plugging MN (SPM) is developed to perform intraocular drug delivery and to seal the scleral puncture simultaneously. The SPMs are fabricated by a thermal drawing process and then coated with a polymeric carrier of drugs and a hydrogel-based scleral plugging component. Each coated functional layer is characterized and demonstrated by in vitro and ex vivo experiments. Finally, in vivo tests using a porcine model confirms prompt sealing of SPM and sustained intraocular drug delivery.",

author = "Lee, {Kang Ju} and Park, {Seung Hyun} and Jo, {Dong Hyun} and Cho, {Chang Sik} and Jang, {Ha Young} and Jiyeon Yi and Minkyung Kang and Jaeho Kim and Jung, {Ho Yun} and Kim, {Jeong Hun} and Ryu, {Won Hyoung} and Ali Khademhosseini",

note = "Funding Information: K.L., S.P. and D.H.J. contributed equally to this work. This research was supported by a grant of National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2021R1F1A105502211 (K.L.)), a grant of Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (HI18C1237 (W.R.)), Global Infrastructure Program through the NRF funded by the MSIT (2019K1A3A1A18116048, (W.R.)), the Basic Science Research Program through the NRF funded by the Ministry of Education (NRF‐2017R1A6A3A04004741 (D.H.J.)), the Creative Materials Discovery Program through the NRF funded by the Ministry of Science and ICT (2018M3D1A1058826 (J.H.K.)), the Development of Platform Technology for Innovative Medical Measurements funded by Korea Research Institute of Standards and Science (KRISS–2021– GP2021‐ 0004 (J.H.K.)). Publisher Copyright: {\textcopyright} 2022 Wiley-VCH GmbH.",

year = "2022",

month = jun,

doi = "10.1002/adhm.202102599",

language = "English",

volume = "11",

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AU - Lee, Kang Ju

AU - Park, Seung Hyun

AU - Jo, Dong Hyun

AU - Cho, Chang Sik

AU - Jang, Ha Young

AU - Yi, Jiyeon

AU - Kang, Minkyung

AU - Kim, Jaeho

AU - Jung, Ho Yun

AU - Kim, Jeong Hun

AU - Ryu, Won Hyoung

AU - Khademhosseini, Ali

N1 - Funding Information: K.L., S.P. and D.H.J. contributed equally to this work. This research was supported by a grant of National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (2021R1F1A105502211 (K.L.)), a grant of Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (HI18C1237 (W.R.)), Global Infrastructure Program through the NRF funded by the MSIT (2019K1A3A1A18116048, (W.R.)), the Basic Science Research Program through the NRF funded by the Ministry of Education (NRF‐2017R1A6A3A04004741 (D.H.J.)), the Creative Materials Discovery Program through the NRF funded by the Ministry of Science and ICT (2018M3D1A1058826 (J.H.K.)), the Development of Platform Technology for Innovative Medical Measurements funded by Korea Research Institute of Standards and Science (KRISS–2021– GP2021‐ 0004 (J.H.K.)). Publisher Copyright: © 2022 Wiley-VCH GmbH.

PY - 2022/6

Y1 - 2022/6

N2 - Intravitreal injection (IVI) is a common technology which is used to treat ophthalmic diseases inside eyeballs by delivering various drugs into the vitreous cavity using hypodermic needles. However, in some cases, there are possible side effects such as ocular tissue damage due to repeated injection or eyeball infection through the hole created during the needle retraction process. The best scenario of IVI is a one-time injection of drugs without needle retraction, keeping the system of the eyeball closed. Microneedles (MNs) have been applied to ocular tissues over 10 years, and no serious side effects on ocular tissue due to MN injection have been reported. Therefore, a self-plugging MN (SPM) is developed to perform intraocular drug delivery and to seal the scleral puncture simultaneously. The SPMs are fabricated by a thermal drawing process and then coated with a polymeric carrier of drugs and a hydrogel-based scleral plugging component. Each coated functional layer is characterized and demonstrated by in vitro and ex vivo experiments. Finally, in vivo tests using a porcine model confirms prompt sealing of SPM and sustained intraocular drug delivery.

AB - Intravitreal injection (IVI) is a common technology which is used to treat ophthalmic diseases inside eyeballs by delivering various drugs into the vitreous cavity using hypodermic needles. However, in some cases, there are possible side effects such as ocular tissue damage due to repeated injection or eyeball infection through the hole created during the needle retraction process. The best scenario of IVI is a one-time injection of drugs without needle retraction, keeping the system of the eyeball closed. Microneedles (MNs) have been applied to ocular tissues over 10 years, and no serious side effects on ocular tissue due to MN injection have been reported. Therefore, a self-plugging MN (SPM) is developed to perform intraocular drug delivery and to seal the scleral puncture simultaneously. The SPMs are fabricated by a thermal drawing process and then coated with a polymeric carrier of drugs and a hydrogel-based scleral plugging component. Each coated functional layer is characterized and demonstrated by in vitro and ex vivo experiments. Finally, in vivo tests using a porcine model confirms prompt sealing of SPM and sustained intraocular drug delivery.

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ER -

Self-Plugging Microneedle (SPM) for Intravitreal Drug Delivery

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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