Self-powered triboelectric aptasensor for label-free highly specific thrombin detection

Yun Kyung Jung, Kyeong Nam Kim, Jeong Min Baik, Byeong-Su Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An aptamer-based triboelectric biosensor is developed for a highly specific, label-free and self-powered detection of thrombin. For the first time, intermolecular recognition interactions are used to develop a selective nanosensor based on triboelectric effect. Positively charged Au nanoparticles (Au NPs+) with large difference in triboelectric polarity and work function are assembled onto Al film to increase the electrical output of triboelectric nanogenerators (TENG). Modification of anti-thrombin aptamers on the Au NPs+-assembled TENG affords the triboelectric nanosensor highly selective toward thrombin, even in clinical samples because of specific binding affinity between aptamers and thrombin unlike random DNA-modified TENGs with undetectable response. A 0.41 nM limit of detection is achieved, which is directly demonstrated by the number of commercial LED lights without any supporting equipment such as power source and electrometer. Our study demonstrates an innovative and unique approach toward the self-powered and label-free detection of thrombin for rapid and simple in-field analysis.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalNano Energy
Volume30
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

Nanosensors
Thrombin
Labels
Electrometers
Biosensors
Light emitting diodes
DNA
Nanoparticles
thrombin aptamer

All Science Journal Classification (ASJC) codes

  • Renewable Energy, Sustainability and the Environment
  • Materials Science(all)
  • Electrical and Electronic Engineering

Cite this

Jung, Yun Kyung ; Kim, Kyeong Nam ; Baik, Jeong Min ; Kim, Byeong-Su. / Self-powered triboelectric aptasensor for label-free highly specific thrombin detection. In: Nano Energy. 2016 ; Vol. 30. pp. 77-83.
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Self-powered triboelectric aptasensor for label-free highly specific thrombin detection. / Jung, Yun Kyung; Kim, Kyeong Nam; Baik, Jeong Min; Kim, Byeong-Su.

In: Nano Energy, Vol. 30, 01.12.2016, p. 77-83.

Research output: Contribution to journalArticle

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