Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

Xia Peng, Mario Urso, Jan Balvan, Michal Masarik, Martin Pumera

Research output: Contribution to journalArticlepeer-review

Abstract

Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.

Original languageEnglish
JournalAngewandte Chemie - International Edition
DOIs
Publication statusAccepted/In press - 2022

Bibliographical note

Funding Information:
M.P. acknowledges the financial support of Grant Agency of the Czech Republic (EXPRO: 19‐26896X). X.P. was supported by the China Scholarship Council (CSC No. 202008320382) and acknowledges the Brno Ph.D. Talent scholarship funded by the Brno City Municipality, and the project Quality Internal Grants of BUT (KInG BUT), reg. no. CZ.02.2.69/0.0/0.0/19_073/0016948, which is financed from the OP RDE. M.U. acknowledges the financial support by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska‐Curie grant agreement No. 101038066. J.B. and M.M. were supported by the Ministry of Health of the Czech Republic (NU21‐08‐00407). CzechNanoLab project LM2018110 funded by MEYS CR is gratefully acknowledged for the financial support of the measurements/sample fabrication at CEITEC Nano Research Infrastructure. CIISB, Instruct‐CZ Centre of Instruct‐ERIC EU consortium, funded by MEYS CR infrastructure project LM2018127, is gratefully acknowledged for the financial support of the measurements at the CEITEC Proteomics Core Facility.

Publisher Copyright:
© 2022 Wiley-VCH GmbH.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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