Self-Propelled Multifunctional Microrobots Harboring Chiral Supramolecular Selectors for “Enantiorecognition-on-the-Fly”

Jose Muñoz, Mario Urso, Martin Pumera

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Herein, a general procedure for the synthesis of multifunctional MRs, which simultaneously exhibit i) chiral, ii) magnetic, and iii) fluorescent properties in combination with iv) self-propulsion, is reported. Self-propelled Ni@Pt superparamagnetic microrockets have been functionalized with fluorescent CdS quantum dots carrying a chiral host biomolecule as β-cyclodextrin (β-CD). The “on-the-fly” chiral recognition potential of MRs has been interrogated by taking advantage of the β-CD affinity to supramolecularly accommodate different chiral biomolecules (i.e., amino acids). As a proof-of-concept, tryptophan enantiomers have been discriminated with a dual-mode (optical and electrochemical) readout. This approach paves the way to devise intelligent cargo micromachines with “built-in” chiral supramolecular recognition capabilities to elucidate the concept of “enantiorecognition-on-the-fly”, which might be facilely customized by tailoring the supramolecular host–guest encapsulation.

Original languageEnglish
Article numbere202116090
JournalAngewandte Chemie - International Edition
Volume61
Issue number14
DOIs
Publication statusPublished - 2022 Mar 28

Bibliographical note

Funding Information:
This work was supported by the project Advanced Functional Nanorobots (reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR) and the Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under an ERC CZ program. J. M. and M.U. acknowledge the financial support from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska‐Curie grant agreements No. 101027867 and No. 101038066, respectively. Finally, the authors acknowldege CzechNanoLab Research Infrastructure supported by LM2018110 MEYS CR 2020‐2022.

Funding Information:
This work was supported by the project Advanced Functional Nanorobots (reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR) and the Ministry of Education, Youth and Sports (Czech Republic) grant LL2002 under an ERC CZ program. J. M. and M.U. acknowledge the financial support from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreements No. 101027867 and No. 101038066, respectively. Finally, the authors acknowldege CzechNanoLab Research Infrastructure supported by LM2018110 MEYS CR 2020-2022.

Publisher Copyright:
© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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