Seminal plasma anaphylaxis: Successful pregnancy after intravaginal desensitization and immunodetection of allergens

Jungwon Park, Si Hwan Ko, Cheol Woo Kim, Sang Wook Bae, Chein Soo Hong

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26 Citations (Scopus)


For seminal plasma-allergic patients to achieve: pregnancy, immunotherapy or artificial insemination is recommended. However, these modalities require complicated procedures. We recently treated a patient with human seminal plasma anaphylaxis who was successfully desensitized after intravaginal rush desensitization and became spontaneously pregnant. She had a healthy full-term infant. With immunoblotting, we identified multiple allergens in her husband's seminal plasma, with molecular masses such as 100, 75, 65, 50, 40, 38, 33, 20, and 18 kDa, and the pattern of immunoblotting did not change after desensitization. We found not only specific antibodies to the seminal plasma of the patient's partner, but also common antibodies to both the partner's and the control specimen. Our results suggest that intravaginal desensitization might be an effective and convenient initial approach for patients who want to achieve pregnancy, and also confirm the presence of both the specific and shared common allergens in the seminal plasmas of the patient's partner and the control subject.

Original languageEnglish
Pages (from-to)990-993
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number9
Publication statusPublished - 1999 Sep 24


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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