Abstract
For seminal plasma-allergic patients to achieve: pregnancy, immunotherapy or artificial insemination is recommended. However, these modalities require complicated procedures. We recently treated a patient with human seminal plasma anaphylaxis who was successfully desensitized after intravaginal rush desensitization and became spontaneously pregnant. She had a healthy full-term infant. With immunoblotting, we identified multiple allergens in her husband's seminal plasma, with molecular masses such as 100, 75, 65, 50, 40, 38, 33, 20, and 18 kDa, and the pattern of immunoblotting did not change after desensitization. We found not only specific antibodies to the seminal plasma of the patient's partner, but also common antibodies to both the partner's and the control specimen. Our results suggest that intravaginal desensitization might be an effective and convenient initial approach for patients who want to achieve pregnancy, and also confirm the presence of both the specific and shared common allergens in the seminal plasmas of the patient's partner and the control subject.
| Original language | English |
|---|---|
| Pages (from-to) | 990-993 |
| Number of pages | 4 |
| Journal | Allergy: European Journal of Allergy and Clinical Immunology |
| Volume | 54 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1999 Sep 24 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
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Seminal plasma anaphylaxis : Successful pregnancy after intravaginal desensitization and immunodetection of allergens. / Park, Jungwon; Ko, Si Hwan; Kim, Cheol Woo; Bae, Sang Wook; Hong, Chein Soo.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 54, No. 9, 24.09.1999, p. 990-993.Research output: Contribution to journal › Article
TY - JOUR
T1 - Seminal plasma anaphylaxis
T2 - Successful pregnancy after intravaginal desensitization and immunodetection of allergens
AU - Park, Jungwon
AU - Ko, Si Hwan
AU - Kim, Cheol Woo
AU - Bae, Sang Wook
AU - Hong, Chein Soo
PY - 1999/9/24
Y1 - 1999/9/24
N2 - For seminal plasma-allergic patients to achieve: pregnancy, immunotherapy or artificial insemination is recommended. However, these modalities require complicated procedures. We recently treated a patient with human seminal plasma anaphylaxis who was successfully desensitized after intravaginal rush desensitization and became spontaneously pregnant. She had a healthy full-term infant. With immunoblotting, we identified multiple allergens in her husband's seminal plasma, with molecular masses such as 100, 75, 65, 50, 40, 38, 33, 20, and 18 kDa, and the pattern of immunoblotting did not change after desensitization. We found not only specific antibodies to the seminal plasma of the patient's partner, but also common antibodies to both the partner's and the control specimen. Our results suggest that intravaginal desensitization might be an effective and convenient initial approach for patients who want to achieve pregnancy, and also confirm the presence of both the specific and shared common allergens in the seminal plasmas of the patient's partner and the control subject.
AB - For seminal plasma-allergic patients to achieve: pregnancy, immunotherapy or artificial insemination is recommended. However, these modalities require complicated procedures. We recently treated a patient with human seminal plasma anaphylaxis who was successfully desensitized after intravaginal rush desensitization and became spontaneously pregnant. She had a healthy full-term infant. With immunoblotting, we identified multiple allergens in her husband's seminal plasma, with molecular masses such as 100, 75, 65, 50, 40, 38, 33, 20, and 18 kDa, and the pattern of immunoblotting did not change after desensitization. We found not only specific antibodies to the seminal plasma of the patient's partner, but also common antibodies to both the partner's and the control specimen. Our results suggest that intravaginal desensitization might be an effective and convenient initial approach for patients who want to achieve pregnancy, and also confirm the presence of both the specific and shared common allergens in the seminal plasmas of the patient's partner and the control subject.
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U2 - 10.1034/j.1398-9995.1999.00129.x
DO - 10.1034/j.1398-9995.1999.00129.x
M3 - Article
C2 - 10505464
AN - SCOPUS:0032854364
VL - 54
SP - 990
EP - 993
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 9
ER -