Abstract
Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during followup (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.
| Original language | English |
|---|---|
| Pages (from-to) | 156-162 |
| Number of pages | 7 |
| Journal | Diabetes |
| Volume | 68 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
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}
Senescent T cells predict the development of hyperglycemia in humans. / Lee, Yong ho; Kim, So Ra; Han, Dai Hoon; Yu, Hee Tae; Han, Yoon Dae; Kim, Jin Hee; Kim, Soo Hyun; Lee, Chan Joo; Min, Byoung Hoon; Kim, Dong Hyun; Kim, Kyung Hwan; Cho, Jin Won; Lee, Won Woo; Shin, Eui Cheol; Park, Sungha.
In: Diabetes, Vol. 68, No. 1, 01.01.2019, p. 156-162.Research output: Contribution to journal › Article
TY - JOUR
T1 - Senescent T cells predict the development of hyperglycemia in humans
AU - Lee, Yong ho
AU - Kim, So Ra
AU - Han, Dai Hoon
AU - Yu, Hee Tae
AU - Han, Yoon Dae
AU - Kim, Jin Hee
AU - Kim, Soo Hyun
AU - Lee, Chan Joo
AU - Min, Byoung Hoon
AU - Kim, Dong Hyun
AU - Kim, Kyung Hwan
AU - Cho, Jin Won
AU - Lee, Won Woo
AU - Shin, Eui Cheol
AU - Park, Sungha
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during followup (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.
AB - Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during followup (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.
UR - http://www.scopus.com/inward/record.url?scp=85058888807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058888807&partnerID=8YFLogxK
U2 - 10.2337/db17-1218
DO - 10.2337/db17-1218
M3 - Article
C2 - 30389747
AN - SCOPUS:85058888807
VL - 68
SP - 156
EP - 162
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 1
ER -