Senescent T cells predict the development of hyperglycemia in humans

Yong ho Lee, So Ra Kim, Dai Hoon Han, Hee Tae Yu, Yoon Dae Han, Jin Hee Kim, Soo Hyun Kim, Chan Joo Lee, Byoung Hoon Min, Dong Hyun Kim, Kyung Hwan Kim, Jin Won Cho, Won Woo Lee, Eui Cheol Shin, Sungha Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during followup (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.

Original languageEnglish
Pages (from-to)156-162
Number of pages7
JournalDiabetes
Volume68
Issue number1
DOIs
Publication statusPublished - 2019 Jan 1

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Hyperglycemia
T-Lymphocytes
Prediabetic State
Type 2 Diabetes Mellitus
Glucose
Intra-Abdominal Fat
T-Lymphocyte Subsets
Chronic Disease
Cardiovascular Diseases

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Lee, Y. H., Kim, S. R., Han, D. H., Yu, H. T., Han, Y. D., Kim, J. H., ... Park, S. (2019). Senescent T cells predict the development of hyperglycemia in humans. Diabetes, 68(1), 156-162. https://doi.org/10.2337/db17-1218
Lee, Yong ho ; Kim, So Ra ; Han, Dai Hoon ; Yu, Hee Tae ; Han, Yoon Dae ; Kim, Jin Hee ; Kim, Soo Hyun ; Lee, Chan Joo ; Min, Byoung Hoon ; Kim, Dong Hyun ; Kim, Kyung Hwan ; Cho, Jin Won ; Lee, Won Woo ; Shin, Eui Cheol ; Park, Sungha. / Senescent T cells predict the development of hyperglycemia in humans. In: Diabetes. 2019 ; Vol. 68, No. 1. pp. 156-162.
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abstract = "Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during followup (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.",
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Lee, YH, Kim, SR, Han, DH, Yu, HT, Han, YD, Kim, JH, Kim, SH, Lee, CJ, Min, BH, Kim, DH, Kim, KH, Cho, JW, Lee, WW, Shin, EC & Park, S 2019, 'Senescent T cells predict the development of hyperglycemia in humans', Diabetes, vol. 68, no. 1, pp. 156-162. https://doi.org/10.2337/db17-1218

Senescent T cells predict the development of hyperglycemia in humans. / Lee, Yong ho; Kim, So Ra; Han, Dai Hoon; Yu, Hee Tae; Han, Yoon Dae; Kim, Jin Hee; Kim, Soo Hyun; Lee, Chan Joo; Min, Byoung Hoon; Kim, Dong Hyun; Kim, Kyung Hwan; Cho, Jin Won; Lee, Won Woo; Shin, Eui Cheol; Park, Sungha.

In: Diabetes, Vol. 68, No. 1, 01.01.2019, p. 156-162.

Research output: Contribution to journalArticle

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AU - Kim, Soo Hyun

AU - Lee, Chan Joo

AU - Min, Byoung Hoon

AU - Kim, Dong Hyun

AU - Kim, Kyung Hwan

AU - Cho, Jin Won

AU - Lee, Won Woo

AU - Shin, Eui Cheol

AU - Park, Sungha

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N2 - Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57+ or CD28null senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (N = 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during followup (mean 2.3 years). CD8+CD57+ and CD8+CD28null T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57+ or CD28null cells in the CD8+ T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8+CD57+ T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8+CD57+ T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8+ T cells in the peripheral blood is associated with development of hyperglycemia.

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Lee YH, Kim SR, Han DH, Yu HT, Han YD, Kim JH et al. Senescent T cells predict the development of hyperglycemia in humans. Diabetes. 2019 Jan 1;68(1):156-162. https://doi.org/10.2337/db17-1218