Sensing the environment: Lessons from fungi

Yong Sun Bahn, Chaoyang Xue, Alexander Idnurm, Julian C. Rutherford, Joseph Heitman, Maria E. Cardenas

Research output: Contribution to journalReview articlepeer-review

233 Citations (Scopus)

Abstract

All living organisms use numerous signal-transduction systems to sense and respond to their environments and thereby survive and proliferate in a range of biological niches. Molecular dissection of these signalling networks has increased our understanding of these communication processes and provides a platform for therapeutic intervention when these pathways malfunction in disease states, including infection. Owing to the expanding availability of sequenced genomes, a wealth of genetic and molecular tools and the conservation of signalling networks, members of the fungal kingdom serve as excellent model systems for more complex, multicellular organisms. Here, we review recent progress in our understanding of how fungal-signalling circuits operate at the molecular level to sense and respond to a plethora of environmental cues.

Original languageEnglish
Pages (from-to)57-69
Number of pages13
JournalNature Reviews Microbiology
Volume5
Issue number1
DOIs
Publication statusPublished - 2007 Jan

Bibliographical note

Funding Information:
The authors thank F. A. Mühlschlegel for providing pictures of C. albicans filamentation. This work was supported by the Soongsil University Research Fund to Y-S.B. and R01 grants from the NIAID/NIH to J.H. and NCI/NIH to M.E.C.

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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