Abstract
In this study, HIV-1 Rev response element (RRE) RNA was detected via an Au-coated vertical silicon nanowire electrode array (VSNEA). The VSNEA was fabricated by combining bottom-up and top-down approaches and then immobilized by artificial peptides for the recognition of HIV-1 RRE. Differential pulse voltammetry (DPV) analysis was used to measure the electrochemical response of the peptide-immobilized VSNEA to the concentration and types of HIV-1 RRE RNA. DPV peaks showed linearity to the concentration of RNA with a detection limit down to 1.513 fM. It also showed the clear different peaks to the mutated HIV-1 RRE RNA. The high sensitivity and selectivity of VSNEA for the detection of HIV-1 RRE RNA may be attributed to the high surface-to-volume ratio and total overlap diffusion mode of ions of the one-dimensional nanowire electrodes.
Original language | English |
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Article number | 341 |
Journal | Nanoscale Research Letters |
Volume | 11 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2016 Dec 1 |
Bibliographical note
Publisher Copyright:© 2016, The Author(s).
All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics