A nanowire-mediated surface plasmon resonance (SPR) imaging is numerically investigated for enhanced sensitivity. The results calculated by rigorous coupled-wave analysis present that interplays between localized surface plasmons and surface plasmon polaritons contribute to sensitivity enhancement. Compared to conventional thin film-based SPR imaging measurement, an optimal nanowire structure can provide sensitivity enhancement by 3.44 times as well as highly linear detection property for quantification of surface reactions of interests. This paper demonstrates the potential and limitation for a highly sensitive, label-free, and real-time SPR imaging sensor based on periodic metallic nanowires.
Bibliographical noteFunding Information:
Manuscript received September 29, 2007; revised February 1, 2008. This work was supported by the International Collaboration Program, NBS-ERC (Nano Bioelectronics and Systems Research Center )/KOSEF (Korea Science and Engineering Foundation). The work of S. J. Yoon and D. Kim was supported by the Korea Science and Engineering Foundation (KOSEF) through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0) and KOSEF 2007-8-1158. Partial support was provided by a grant to the MEMS Research Center for National Defense funded by Defense Acquisition Program Administration under 2006-MM-41-5ND0600407. This work was also supported by the IT R&D program of MIC/IITA [2007-S001-01, Development of Implantable System Based on Biomedical Signal Processing], and by the “System IC 2010” project of Ministry of Knowledge Economy.
All Science Journal Classification (ASJC) codes
- Atomic and Molecular Physics, and Optics