Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron

Kyoung Ran Kim, Yong Deok Lee, Taemin Lee, Byeong-Su Kim, Sehoon Kim, Dae Ro Ahn

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Sentinel lymph nodes (SLNs) are the first lymph nodes which cancer cells reach after traveling through lymphatic vessels from the primary tumor. Evaluating the nodal status is crucial in accurate staging of human cancers and accordingly determines prognosis and the most appropriate treatment. The commonly used methods for SLN identification in clinics are based on employment of a colloid of radionuclide or injection of a small dye. Although these methods have certainly contributed to improve surgical practice, new imaging materials are still required to overcome drawbacks of the techniques such as inconvenience of handling radioactive materials and short retention time of small dyes in SLNs. Here, we prepare a fluorescence-labeled DNA tetrahedron and perform SLN imaging by using the DNA nanoconstruct. With a successful identification of SLNs by the DNA nanoconstruct, we suggest that DNA tetrahedron hold great promises for clinical applications.

Original languageEnglish
Pages (from-to)5226-5235
Number of pages10
JournalBiomaterials
Volume34
Issue number21
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

DNA
Imaging techniques
Dyes
Lymphatic Vessel Tumors
Coloring Agents
Radioactive materials
Colloids
Radioisotopes
Neoplasm Staging
Tumors
Fluorescence
Cells
Lymph Nodes
cyhalothrin
Sentinel Lymph Node
Injections
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Kim, Kyoung Ran ; Lee, Yong Deok ; Lee, Taemin ; Kim, Byeong-Su ; Kim, Sehoon ; Ahn, Dae Ro. / Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron. In: Biomaterials. 2013 ; Vol. 34, No. 21. pp. 5226-5235.
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Sentinel lymph node imaging by a fluorescently labeled DNA tetrahedron. / Kim, Kyoung Ran; Lee, Yong Deok; Lee, Taemin; Kim, Byeong-Su; Kim, Sehoon; Ahn, Dae Ro.

In: Biomaterials, Vol. 34, No. 21, 01.07.2013, p. 5226-5235.

Research output: Contribution to journalArticle

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