Sentinel lymph nodes (SLNs) are the first lymph nodes which cancer cells reach after traveling through lymphatic vessels from the primary tumor. Evaluating the nodal status is crucial in accurate staging of human cancers and accordingly determines prognosis and the most appropriate treatment. The commonly used methods for SLN identification in clinics are based on employment of a colloid of radionuclide or injection of a small dye. Although these methods have certainly contributed to improve surgical practice, new imaging materials are still required to overcome drawbacks of the techniques such as inconvenience of handling radioactive materials and short retention time of small dyes in SLNs. Here, we prepare a fluorescence-labeled DNA tetrahedron and perform SLN imaging by using the DNA nanoconstruct. With a successful identification of SLNs by the DNA nanoconstruct, we suggest that DNA tetrahedron hold great promises for clinical applications.
|Number of pages||10|
|Publication status||Published - 2013 Jul|
Bibliographical noteFunding Information:
This study was supported by a grant funded by Korea Institute of Science and Technology , a grant of the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education ( 2011-0009172 ), a grant the Proteogenomic Research Program through the National Research Foundation of Korea funded by the Korean Ministry of Education, Science and Technology , and a grant of the Korea Healthcare technology R&D Project , the Ministry of Health & Welfare, Republic of Korea ( A121191 ).
All Science Journal Classification (ASJC) codes
- Ceramics and Composites
- Mechanics of Materials