Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1)

Moo Gak Hwang, In Kwon Chung, Bin Goo Kang, Myeon Haeng Cho

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)

Abstract

We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. AtTBP1 is present as a single-copy gene in Arabidopsis genome and is expressed ubiquitously in various organs. AtTBP1 has a single Myb telomeric DNA binding domain at the C-terminus and an extensive homology with other known telomere-binding proteins. The isolated C-terminus of AtTBP1 is capable of sequence-specific DNA binding to plant duplex telomeric DNA. These results suggest that AtTBP1 may play important roles in plant telomere function in vivo.

Original languageEnglish
Pages (from-to)35-40
Number of pages6
JournalFEBS Letters
Volume503
Issue number1
DOIs
Publication statusPublished - 2001 Aug 10

Bibliographical note

Funding Information:
This work was supported in part by Grant 1999-015-DP0389 and Grant 2000-015-DP0400 from the Korea Research Foundation.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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