Sequential therapy versus triple therapy for the first line treatment of helicobacter pylori in korea: A nationwide randomized trial

Joon Sung Kim, Byung Wook Kim, Su Jin Hong, Jin Il Kim, Ki Nam Shim, Jie Hyun Kim, Gwang Ho Baik, Sang Wook Kim, Hyun Joo Song, Ji Hyun Kim

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13 Citations (Scopus)

Abstract

Background/Aims: Eradication of Helicobacter pylori infection with standard triple therapy (TT) has declined primarily because of increased antibiotic resistance. Sequential therapy (ST) has been suggested as an alternative to TT for the first-line treatment of H. pylori. The purpose of this study was to compare the efficacy of ST with TT. Methods: This was a multicenter, randomized open-label trial performed at nine centers in Korea. Patients with H. pylori infection were randomly assigned to receive either 7 day TT or 10 day ST. Eradication rates, drug compliance, and adverse events were compared among the two regimens. Results: A total of 601 patients were enrolled between March 2011 and September 2014. The intention-to-treat eradication rates were 70.8% for TT and 82.4% for ST (p=0.001). The corresponding per protocol eradication rates were 76.9% and 88.8% for TT and ST, respectively (p=0.000). There were no statistically significant differences between the two regimens with respect to drug compliance and adverse events. Conclusions: ST achieved better eradication rates than TT as a first-line therapy for H. pylori eradication in Korea.

Original languageEnglish
Pages (from-to)556-561
Number of pages6
JournalGut and liver
Volume10
Issue number4
DOIs
Publication statusPublished - 2016 Jul

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Kim, J. S., Kim, B. W., Hong, S. J., Kim, J. I., Shim, K. N., Kim, J. H., Baik, G. H., Kim, S. W., Song, H. J., & Kim, J. H. (2016). Sequential therapy versus triple therapy for the first line treatment of helicobacter pylori in korea: A nationwide randomized trial. Gut and liver, 10(4), 556-561. https://doi.org/10.5009/gnl15470