Serial assessment of myocardial properties using cyclic variation of integrated backscatter in an adriamycin-induced cardiomyopathy rat model

Jong Won Ha, Seok Min Kang, Wook Bum Pyun, Joo Yong Lee, Mi Young Ahn, Woong Chul Kang, Tae Joo Jeon, Namsik Chung, Jong Doo Lee, Sang Ho Cho

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although adriamycin (Doxorubicin) is one of the most effective and useful antineoplastic agents for the treatment of a variety of malignancies, its repeated administration can induce irreversible myocardial damage and resultant heart failure. Currently, no marker to detect early cardiac damage is available. The purpose of this study was to investigate whether an assessment of the acoustic properties of the myocardium could enable the earlier detection of myocardial damage after adriamycin chemotherapy. Forty Wistar rats were treated with adriamycin (2 mg/kg, i.v.) once a week for 2, 4, 6 or 8 weeks consecutively. Left ventricular ejection fraction (LVEF) was calculated using M-mode echocardiography data. The magnitude of cardiac cycle dependent variation of integrated backscatter (CVIB) of the myocardium was measured in the mid segment of the septum and in the posterior wall of the left ventricle, using a real time two dimensional integrated backscatter imaging system. LVEF was significantly lower in the adriamycin-treated 8-week group than in the controls (75 ± 9 vs 57 ± 8%, p<0.05). Myocyte damage was only seen in the 8-week adriamycin-treated group. However, no significant changes of CVIB were observed between base-line or during follow-up in the ADR or control group. In conclusion, serial assessment of the acoustic properties of the myocardium may not be an optimal tool for the early detection of myocardial damage after doxorubicin chemotherapy in a rat model.

Original languageEnglish
Pages (from-to)73-77
Number of pages5
JournalYonsei medical journal
Volume46
Issue number1
DOIs
Publication statusPublished - 2005 Feb 28

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Cardiomyopathies
Doxorubicin
Myocardium
Acoustics
Stroke Volume
Drug Therapy
Control Groups
Antineoplastic Agents
Muscle Cells
Heart Ventricles
Echocardiography
Wistar Rats
Heart Failure
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ha, Jong Won ; Kang, Seok Min ; Pyun, Wook Bum ; Lee, Joo Yong ; Ahn, Mi Young ; Kang, Woong Chul ; Jeon, Tae Joo ; Chung, Namsik ; Lee, Jong Doo ; Cho, Sang Ho. / Serial assessment of myocardial properties using cyclic variation of integrated backscatter in an adriamycin-induced cardiomyopathy rat model. In: Yonsei medical journal. 2005 ; Vol. 46, No. 1. pp. 73-77.
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Serial assessment of myocardial properties using cyclic variation of integrated backscatter in an adriamycin-induced cardiomyopathy rat model. / Ha, Jong Won; Kang, Seok Min; Pyun, Wook Bum; Lee, Joo Yong; Ahn, Mi Young; Kang, Woong Chul; Jeon, Tae Joo; Chung, Namsik; Lee, Jong Doo; Cho, Sang Ho.

In: Yonsei medical journal, Vol. 46, No. 1, 28.02.2005, p. 73-77.

Research output: Contribution to journalArticle

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AU - Ha, Jong Won

AU - Kang, Seok Min

AU - Pyun, Wook Bum

AU - Lee, Joo Yong

AU - Ahn, Mi Young

AU - Kang, Woong Chul

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AU - Lee, Jong Doo

AU - Cho, Sang Ho

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N2 - Although adriamycin (Doxorubicin) is one of the most effective and useful antineoplastic agents for the treatment of a variety of malignancies, its repeated administration can induce irreversible myocardial damage and resultant heart failure. Currently, no marker to detect early cardiac damage is available. The purpose of this study was to investigate whether an assessment of the acoustic properties of the myocardium could enable the earlier detection of myocardial damage after adriamycin chemotherapy. Forty Wistar rats were treated with adriamycin (2 mg/kg, i.v.) once a week for 2, 4, 6 or 8 weeks consecutively. Left ventricular ejection fraction (LVEF) was calculated using M-mode echocardiography data. The magnitude of cardiac cycle dependent variation of integrated backscatter (CVIB) of the myocardium was measured in the mid segment of the septum and in the posterior wall of the left ventricle, using a real time two dimensional integrated backscatter imaging system. LVEF was significantly lower in the adriamycin-treated 8-week group than in the controls (75 ± 9 vs 57 ± 8%, p<0.05). Myocyte damage was only seen in the 8-week adriamycin-treated group. However, no significant changes of CVIB were observed between base-line or during follow-up in the ADR or control group. In conclusion, serial assessment of the acoustic properties of the myocardium may not be an optimal tool for the early detection of myocardial damage after doxorubicin chemotherapy in a rat model.

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