Serial intravascular ultrasound evidence of both plaque stabilization and lesion progression in patients with ruptured coronary plaques: Effects of statin therapy on ruptured coronary plaque

Myeong Ki Hong, Gary S. Mintz, Cheol Whan Lee, Il Woo Suh, Eui Seok Hwang, Young Hoon Jeong, Duk Woo Park, Young Hak Kim, Ki Hoon Han, Sang Sig Cheong, Jae Joong Kim, Seong Wook Park, Seung Jung Park

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Abstract

Using serial intravascular ultrasound (IVUS), we evaluated the natural evolution of non-culprit/non-target lesion ruptured coronary plaques and assessed the impact of statin therapy. Twenty-eight patients with non-stenotic ruptured plaques underwent baseline and 12-month follow-up IVUS studies; half were treated with statins. Standard IVUS analyses were performed. Complete healing of ruptured plaques was observed in four (29%) statin-treated patients and no non-statin-treated patients (p = 0.049). Statin-treated patients had an increase in lumen area of 0.4 ± 0.8 mm2 (versus a decrease in lumen area of -0.6 ± 1.0 mm2 in non-statin-treated patients, p = 0.007) and no change in plaque area (versus an increase in plaque area of 0.6 ± 0.9 mm2, p = 0.051). During 1-year follow-up, target lesion revascularization was performed in three non-statin-treated patients (21%) and no statin-treated patient (p = 0.11). Compared to lesions that did not require revascularization, lesions requiring revascularization had a decrease in lumen area (-1.7 ± 1.4 mm2 versus 0.1 ± 0.8 mm2, p = 0.001) as well as an increase in plaque area (1.6 ± 1.0 mm2 versus 0.1 ± 0.7 mm2, p = 0.002). In conclusion, the current observational follow-up IVUS study showed beneficial effects of statin treatment on reduction of revascularization rates and stabilization of non-culprit/non-target lesion plaque ruptures without significant stenosis. Conversely, healing of non-statin-treated non-culprit/non-target lesion plaque ruptures can be responsible for lesion progression requiring revascularization.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalAtherosclerosis
Volume191
Issue number1
DOIs
Publication statusPublished - 2007 Mar 1

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All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Hong, M. K., Mintz, G. S., Lee, C. W., Suh, I. W., Hwang, E. S., Jeong, Y. H., Park, D. W., Kim, Y. H., Han, K. H., Cheong, S. S., Kim, J. J., Park, S. W., & Park, S. J. (2007). Serial intravascular ultrasound evidence of both plaque stabilization and lesion progression in patients with ruptured coronary plaques: Effects of statin therapy on ruptured coronary plaque. Atherosclerosis, 191(1), 107-114. https://doi.org/10.1016/j.atherosclerosis.2006.02.040