Serially Ordered Magnetization of Nanoclusters via Control of Various Transition Metal Dopants for the Multifractionation of Cells in Microfluidic Magnetophoresis Devices

Byunghoon Kang, Bumjoon Cha, Bongsoo Kim, Seungmin Han, Moo Kwang Shin, Eunji Jang, Hyun Ouk Kim, Seo Ryung Bae, Unyong Jeong, Il Moon, Hye Yeong Son, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A novel method (i.e., continuous magnetic cell separation in a microfluidic channel) is demonstrated to be capable of inducing multifractionation of mixed cell suspensions into multiple outlet fractions. Here, multicomponent cell separation is performed with three different distinguishable magnetic nanoclusters (MnFe2O4, Fe3O4, and CoFe2O4), which are tagged on A431 cells. Because of their mass magnetizations, which can be ideally altered by doping with magnetic atom compositions (Mn, Fe, and Co), the trajectories of cells with each magnetic nanocluster in a flow are shown to be distinct when dragged under the same external magnetic field; the rest of the magnetic characteristics of the nanoclusters are identically fixed. This proof of concept study, which utilizes the magnetization-controlled nanoclusters (NCs), suggests that precise and effective multifractionation is achievable with high-throughput and systematic accuracy for dynamic cell separation.

Original languageEnglish
Pages (from-to)1078-1082
Number of pages5
JournalAnalytical Chemistry
Volume88
Issue number2
DOIs
Publication statusPublished - 2016 Jan 19

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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