Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016

Korean College of Helicobacter and Upper Gastrointestinal Research

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables. Methods: We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay. Results: We analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P <.0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30-39 years and 57.7% in those aged 40-49 years) and was lower in city residents than in noncity residents at all ages. Conclusions: Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori-related policies.

Original languageEnglish
Article numbere12463
JournalHelicobacter
Volume23
Issue number2
DOIs
Publication statusPublished - 2018 Apr

Fingerprint

Seroepidemiologic Studies
Korea
Helicobacter pylori
Multicenter Studies
Helicobacter
Population Characteristics
Serum
Immunoenzyme Techniques
Immunoglobulin G
Demography
Research

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Infectious Diseases

Cite this

Korean College of Helicobacter and Upper Gastrointestinal Research. / Seroprevalence of Helicobacter pylori in Korea : A multicenter, nationwide study conducted in 2015 and 2016. In: Helicobacter. 2018 ; Vol. 23, No. 2.
@article{dface2ca78584c4fa6d472c5bb4e3f6a,
title = "Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016",
abstract = "Background: The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables. Methods: We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay. Results: We analyzed 4917 samples (4917/4920 = 99.9{\%}) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0{\%} (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P <.0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5{\%}), Chungcheong (59.2{\%}), Kyungsang (55.1{\%}), Jeju (54.4{\%}), Gangwon (49.1{\%}), Seoul (47.4{\%}), and Gyeonggi (44.6{\%}). The rate was higher in those older than 40 years (38.1{\%} in those aged 30-39 years and 57.7{\%} in those aged 40-49 years) and was lower in city residents than in noncity residents at all ages. Conclusions: Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori-related policies.",
author = "{Korean College of Helicobacter and Upper Gastrointestinal Research} and Lee, {Jeong Hoon} and Choi, {Kee Don} and Jung, {Hwoon Yong} and Baik, {Gwang Ho} and Park, {Jong Kyu} and Kim, {Sung Soo} and Kim, {Byung Wook} and Hong, {Su Jin} and Hyun Lim and Shin, {Cheol Min} and Lee, {Si Hyung} and Jeon, {Seong Woo} and Kim, {Ji Hyun} and Choi, {Cheol Woong} and Jung, {Hye Kyung} and Kim, {Jie Hyun} and Choi, {Suck Chei} and Cho, {Jin Woong} and Lee, {Wan Sik} and Na, {Soo Young} and Sung, {Jae Kyu} and Song, {Kyung Ho} and Chung, {Jun Won} and Yun, {Sung Cheol}",
year = "2018",
month = "4",
doi = "10.1111/hel.12463",
language = "English",
volume = "23",
journal = "Helicobacter",
issn = "1083-4389",
publisher = "Wiley-Blackwell",
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}

Korean College of Helicobacter and Upper Gastrointestinal Research 2018, 'Seroprevalence of Helicobacter pylori in Korea: A multicenter, nationwide study conducted in 2015 and 2016', Helicobacter, vol. 23, no. 2, e12463. https://doi.org/10.1111/hel.12463

Seroprevalence of Helicobacter pylori in Korea : A multicenter, nationwide study conducted in 2015 and 2016. / Korean College of Helicobacter and Upper Gastrointestinal Research.

In: Helicobacter, Vol. 23, No. 2, e12463, 04.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Seroprevalence of Helicobacter pylori in Korea

T2 - A multicenter, nationwide study conducted in 2015 and 2016

AU - Korean College of Helicobacter and Upper Gastrointestinal Research

AU - Lee, Jeong Hoon

AU - Choi, Kee Don

AU - Jung, Hwoon Yong

AU - Baik, Gwang Ho

AU - Park, Jong Kyu

AU - Kim, Sung Soo

AU - Kim, Byung Wook

AU - Hong, Su Jin

AU - Lim, Hyun

AU - Shin, Cheol Min

AU - Lee, Si Hyung

AU - Jeon, Seong Woo

AU - Kim, Ji Hyun

AU - Choi, Cheol Woong

AU - Jung, Hye Kyung

AU - Kim, Jie Hyun

AU - Choi, Suck Chei

AU - Cho, Jin Woong

AU - Lee, Wan Sik

AU - Na, Soo Young

AU - Sung, Jae Kyu

AU - Song, Kyung Ho

AU - Chung, Jun Won

AU - Yun, Sung Cheol

PY - 2018/4

Y1 - 2018/4

N2 - Background: The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables. Methods: We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay. Results: We analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P <.0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30-39 years and 57.7% in those aged 40-49 years) and was lower in city residents than in noncity residents at all ages. Conclusions: Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori-related policies.

AB - Background: The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables. Methods: We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay. Results: We analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P <.0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30-39 years and 57.7% in those aged 40-49 years) and was lower in city residents than in noncity residents at all ages. Conclusions: Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori-related policies.

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U2 - 10.1111/hel.12463

DO - 10.1111/hel.12463

M3 - Article

C2 - 29345022

AN - SCOPUS:85040730232

VL - 23

JO - Helicobacter

JF - Helicobacter

SN - 1083-4389

IS - 2

M1 - e12463

ER -