Seroprevalence of tuberculosis in domesticated elk (Cervus canadensis) in Korea

Shin Seok Kang, Hyeon Seop Byeon, Bok Kyung Ku, Sang Woo Kim, Jiro Kim, Jeongim Woo, Byeongwoo Ahn, Soojin Kim, Sezim Monoldorova, Chan Ho Park, Sangnae Cho, Bo Young Jeon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Tuberculosis is a contagious disease in animals, primarily cattle, although it also affects wild animals and humans. There are few data on the state of tuberculosis in domesticated elk (Cervus canadensis) in Korea. In order to investigate tuberculosis in elk, the effectiveness of an enzyme linked immunosorbent assay (ELISA) using MPB70 and MPB83 antigens was compared with the tuberculin skin test (TST), and seroprevalence was measured with this assay using serum samples collected from domesticated elk herds in Korea. The respective sensitivities of the MPB70 and MPB83 ELISAs were 51.9% (95% CI 42.0-61.6) and 49.1% (95% CI 39.3-58.9), and their specificities were 100.0% (95% CI 92.6-100.0) and 97.9% (95% CI 88.9-100.0), respectively, in comparison with the TST. The herd prevalence ranged from 50 to 80% and the mean herd seropositive rate was 67.7% (21 of 31). Of 819 serum samples, 163 (19.9%) were seropositive, and the within-region prevalence ranged from 18.5-58.0%. In conclusion, the ELISA using the MPB70 and MPB83 antigens showed moderate sensitivity and high specificity compared to TST in elk, and tuberculosis was assumed to be fairly prevalent in domesticated elk in Korea.

Original languageEnglish
Pages (from-to)228-232
Number of pages5
JournalResearch in Veterinary Science
Volume107
DOIs
Publication statusPublished - 2016 Aug 1

Fingerprint

Cervus elaphus canadensis
elks
Seroepidemiologic Studies
Korea
tuberculosis
seroprevalence
Tuberculin Test
Korean Peninsula
Tuberculosis
Skin Tests
tuberculin
skin tests
Enzyme-Linked Immunosorbent Assay
herds
enzyme-linked immunosorbent assay
Antigens
Animal Diseases
Wild Animals
antigens
Serum

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Kang, S. S., Byeon, H. S., Ku, B. K., Kim, S. W., Kim, J., Woo, J., ... Jeon, B. Y. (2016). Seroprevalence of tuberculosis in domesticated elk (Cervus canadensis) in Korea. Research in Veterinary Science, 107, 228-232. https://doi.org/10.1016/j.rvsc.2016.06.013
Kang, Shin Seok ; Byeon, Hyeon Seop ; Ku, Bok Kyung ; Kim, Sang Woo ; Kim, Jiro ; Woo, Jeongim ; Ahn, Byeongwoo ; Kim, Soojin ; Monoldorova, Sezim ; Park, Chan Ho ; Cho, Sangnae ; Jeon, Bo Young. / Seroprevalence of tuberculosis in domesticated elk (Cervus canadensis) in Korea. In: Research in Veterinary Science. 2016 ; Vol. 107. pp. 228-232.
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abstract = "Tuberculosis is a contagious disease in animals, primarily cattle, although it also affects wild animals and humans. There are few data on the state of tuberculosis in domesticated elk (Cervus canadensis) in Korea. In order to investigate tuberculosis in elk, the effectiveness of an enzyme linked immunosorbent assay (ELISA) using MPB70 and MPB83 antigens was compared with the tuberculin skin test (TST), and seroprevalence was measured with this assay using serum samples collected from domesticated elk herds in Korea. The respective sensitivities of the MPB70 and MPB83 ELISAs were 51.9{\%} (95{\%} CI 42.0-61.6) and 49.1{\%} (95{\%} CI 39.3-58.9), and their specificities were 100.0{\%} (95{\%} CI 92.6-100.0) and 97.9{\%} (95{\%} CI 88.9-100.0), respectively, in comparison with the TST. The herd prevalence ranged from 50 to 80{\%} and the mean herd seropositive rate was 67.7{\%} (21 of 31). Of 819 serum samples, 163 (19.9{\%}) were seropositive, and the within-region prevalence ranged from 18.5-58.0{\%}. In conclusion, the ELISA using the MPB70 and MPB83 antigens showed moderate sensitivity and high specificity compared to TST in elk, and tuberculosis was assumed to be fairly prevalent in domesticated elk in Korea.",
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Kang, SS, Byeon, HS, Ku, BK, Kim, SW, Kim, J, Woo, J, Ahn, B, Kim, S, Monoldorova, S, Park, CH, Cho, S & Jeon, BY 2016, 'Seroprevalence of tuberculosis in domesticated elk (Cervus canadensis) in Korea', Research in Veterinary Science, vol. 107, pp. 228-232. https://doi.org/10.1016/j.rvsc.2016.06.013

Seroprevalence of tuberculosis in domesticated elk (Cervus canadensis) in Korea. / Kang, Shin Seok; Byeon, Hyeon Seop; Ku, Bok Kyung; Kim, Sang Woo; Kim, Jiro; Woo, Jeongim; Ahn, Byeongwoo; Kim, Soojin; Monoldorova, Sezim; Park, Chan Ho; Cho, Sangnae; Jeon, Bo Young.

In: Research in Veterinary Science, Vol. 107, 01.08.2016, p. 228-232.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Seroprevalence of tuberculosis in domesticated elk (Cervus canadensis) in Korea

AU - Kang, Shin Seok

AU - Byeon, Hyeon Seop

AU - Ku, Bok Kyung

AU - Kim, Sang Woo

AU - Kim, Jiro

AU - Woo, Jeongim

AU - Ahn, Byeongwoo

AU - Kim, Soojin

AU - Monoldorova, Sezim

AU - Park, Chan Ho

AU - Cho, Sangnae

AU - Jeon, Bo Young

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Tuberculosis is a contagious disease in animals, primarily cattle, although it also affects wild animals and humans. There are few data on the state of tuberculosis in domesticated elk (Cervus canadensis) in Korea. In order to investigate tuberculosis in elk, the effectiveness of an enzyme linked immunosorbent assay (ELISA) using MPB70 and MPB83 antigens was compared with the tuberculin skin test (TST), and seroprevalence was measured with this assay using serum samples collected from domesticated elk herds in Korea. The respective sensitivities of the MPB70 and MPB83 ELISAs were 51.9% (95% CI 42.0-61.6) and 49.1% (95% CI 39.3-58.9), and their specificities were 100.0% (95% CI 92.6-100.0) and 97.9% (95% CI 88.9-100.0), respectively, in comparison with the TST. The herd prevalence ranged from 50 to 80% and the mean herd seropositive rate was 67.7% (21 of 31). Of 819 serum samples, 163 (19.9%) were seropositive, and the within-region prevalence ranged from 18.5-58.0%. In conclusion, the ELISA using the MPB70 and MPB83 antigens showed moderate sensitivity and high specificity compared to TST in elk, and tuberculosis was assumed to be fairly prevalent in domesticated elk in Korea.

AB - Tuberculosis is a contagious disease in animals, primarily cattle, although it also affects wild animals and humans. There are few data on the state of tuberculosis in domesticated elk (Cervus canadensis) in Korea. In order to investigate tuberculosis in elk, the effectiveness of an enzyme linked immunosorbent assay (ELISA) using MPB70 and MPB83 antigens was compared with the tuberculin skin test (TST), and seroprevalence was measured with this assay using serum samples collected from domesticated elk herds in Korea. The respective sensitivities of the MPB70 and MPB83 ELISAs were 51.9% (95% CI 42.0-61.6) and 49.1% (95% CI 39.3-58.9), and their specificities were 100.0% (95% CI 92.6-100.0) and 97.9% (95% CI 88.9-100.0), respectively, in comparison with the TST. The herd prevalence ranged from 50 to 80% and the mean herd seropositive rate was 67.7% (21 of 31). Of 819 serum samples, 163 (19.9%) were seropositive, and the within-region prevalence ranged from 18.5-58.0%. In conclusion, the ELISA using the MPB70 and MPB83 antigens showed moderate sensitivity and high specificity compared to TST in elk, and tuberculosis was assumed to be fairly prevalent in domesticated elk in Korea.

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