Serotonin transporter gene polymorphism and migraine in the Korean population

Woo Kyung Kim, Hyonsuk Kim, Won Joo Kim, Kyung Yul Lee, HyoJin Park, Chan Hyung Kim, Se Joo Kim, Youngchul Choi

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Abstract

Objective. - To evaluate the association between a serotonin (5-HT) transporter gene polymorphism and migraines in Koreans. Background. - The 5-HT metabolism is believed to play an important part in the pathophysiology of migraines, and a polymorphism of the serotonin transporter (5-HTT) promoter region might influence 5-HTT expression and serotonin uptake. Methods. - This study compared 52 patients with migraine and 170 healthy control subjects in order to determine the association between a polymorphism of the 5-HTT gene-linked polymorphic region (5-HTTLPR) and migraine. Using PCR techniques, the products of the 484-base pair (bp) fragments were denoted as being short alleles (s) and those of 528 bp as being long (1). Results. - The genotype distribution of the healthy controls was s/s (56.5%), s/1 (38.2%), and l/l (5.3%) and that of the patients with migraine was 65.4%, 30.8%, and 3.8%, respectively. No significant differences were noted in the genotype and allele frequencies of 5-HTTLPR between the patients with migraine and the control subjects. Conclusions. - A 5-HTTLPR polymorphism does not appear to be involved in the genetic predisposition to migraines.

Original languageEnglish
Pages (from-to)1056-1060
Number of pages5
JournalHeadache
Volume45
Issue number8
DOIs
Publication statusPublished - 2005 Dec 1

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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