Serotype distribution and antimicrobial resistance of invasive and noninvasive streptococcus pneumoniae isolates in korea between 2014 and 2016

Dong Chul Park, Si Hyun Kim, Dongeun Yong, In Bum Suh, Young Ree Kim, Jongyoun Yi, Wonkeun Song, Sae Am Song, Hee Won Moon, Hae Kyung Lee, Kyoung Un Park, Sunjoo Kim, Seok Hoon Jeong, Jaehyeon Lee, Joseph Jeong, Yu Kyung Kim, Miae Lee, Jihyun Cho, Jong Wan Kim, Kyeong Seob ShinSang Hyun Hwang, Jae Woo Chung, Hye In Woo, Chae Hoon Lee, Namhee Ryoo, Chulhun L. Chang, Hyun Soo Kim, Jayoung Kim, Jong Hee Shin, Soo Hyun Kim, Mi Kyung Lee, Seong Gyu Lee, Sook Jin Jang, Kyutaeg Lee, Hunsuk Suh, Yong Hak Sohn, Min Jung Kwon, Hee Joo Lee, Ki Ho Hong, Kwang Sook Woo, Chul Min Park, Jeong Hwan Shin

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Background: Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the serotype distribution and antimicrobial resistance of S. pneumoniae isolated between 2014 and 2016 in Korea. Methods: We collected a total of 1,855 S. pneumoniae isolates from 44 hospitals between May 2014 and May 2016, and analyzed the serotypes by sequential multiplex PCR. We investigated the distribution of each serotype by patient age, source of the clinical specimen, and antimicrobial resistance pattern. Results: The most common serotypes were 11A (10.1%), followed by 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), and 35B (6.2%). The major invasive serotypes were 3 (12.6%), 19A (7.8%), 34 (7.8%), 10A (6.8%), and 11A (6.8%). Serotypes 10A, 15B, 19A, and 12F were more common in patients ≤5 years old, while serotype 3 was more common in patients ≥65 years old compared with the other age groups. The coverage rates of pneumococcal conjugate vaccine (PCV)7, PCV10, PCV13, and pneumococcal polysaccharide vaccine 23 were 11.8%, 12.12%, 33.3%, and 53.6%, respectively. Of the 1,855 isolates, 857 (46.2%) were multi-drug resistant (MDR), with serotypes 11A and 19A predominant among the MDR strains. The resistance rates against penicillin, cefotaxime, and levofloxacin were 22.8%, 12.5%, and 9.4%, respectively. Conclusions: There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ≤5 years old following the introduction of national immunization programs with the 10- A nd 13-polyvalent vaccines.

Original languageEnglish
Pages (from-to)537-544
Number of pages8
JournalAnnals of laboratory medicine
Volume39
Issue number6
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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    Park, D. C., Kim, S. H., Yong, D., Suh, I. B., Kim, Y. R., Yi, J., Song, W., Song, S. A., Moon, H. W., Lee, H. K., Park, K. U., Kim, S., Jeong, S. H., Lee, J., Jeong, J., Kim, Y. K., Lee, M., Cho, J., Kim, J. W., ... Shin, J. H. (2019). Serotype distribution and antimicrobial resistance of invasive and noninvasive streptococcus pneumoniae isolates in korea between 2014 and 2016. Annals of laboratory medicine, 39(6), 537-544. https://doi.org/10.3343/alm.2019.39.6.606