Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)

B. Jais, V. Rebours, G. Malleo, R. Salvia, M. Fontana, L. Maggino, C. Bassi, R. Manfredi, R. Moran, A. M. Lennon, A. Zaheer, C. Wolfgang, R. Hruban, G. Marchegiani, C. Fernández Del Castillo, W. Brugge, Y. Ha, M. H. Kim, D. Oh, I. HiraiW. Kimura, J. Y. Jang, S. W. Kim, W. Jung, H. Kang, S. Y. Song, C. M. Kang, W. J. Lee, S. Crippa, M. Falconi, I. Gomatos, J. Neoptolemos, A. C. Milanetto, C. Sperti, C. Ricci, R. Casadei, M. Bissolati, G. Balzano, I. Frigerio, R. Girelli, M. Delhaye, B. Bernier, H. Wang, K. T. Jang, D. H. Song, M. T. Huggett, K. W. Oppong, L. Pererva, K. V. Kopchak, M. Del Chiaro, R. Segersvard, L. S. Lee, D. Conwell, A. Osvaldt, V. Campos, G. Aguero Garcete, B. Napoleon, I. Matsumoto, M. Shinzeki, F. Bolado, J. M. Urman Fernandez, M. G. Keane, S. P. Pereira, I. Araujo Acuna, E. C. Vaquero, M. R. Angiolini, A. Zerbi, J. Tang, R. W. Leong, A. Faccinetto, G. Morana, M. C. Petrone, P. G. Arcidiacono, J. H. Moon, H. J. Choi, R. S. Gill, D. Pavey, M. Ouaïssi, B. Sastre, M. Spandre, C. G. De Angelis, M. A. Rios-Vives, M. Concepcion-Martin, T. Ikeura, K. Okazaki, L. Frulloni, O. Messina, P. Lévy

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Objectives Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. Design Retrospective multinational study including SCN diagnosed between 1990 and 2014. Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4- 140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/ year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN's related mortality was 0.1% (n=1).

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalGut
Volume65
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Jais, B., Rebours, V., Malleo, G., Salvia, R., Fontana, M., Maggino, L., Bassi, C., Manfredi, R., Moran, R., Lennon, A. M., Zaheer, A., Wolfgang, C., Hruban, R., Marchegiani, G., Fernández Del Castillo, C., Brugge, W., Ha, Y., Kim, M. H., Oh, D., ... Lévy, P. (2016). Serous cystic neoplasm of the pancreas: A multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas). Gut, 65(2), 305-312. https://doi.org/10.1136/gutjnl-2015-309638