Serum 25-hydroxyvitamin D and insulin resistance in apparently healthy adolescents

Dong Phil Choi, Sun Min Oh, Ju Mi Lee, Hye Min Cho, Won Joon Lee, Bo Mi Song, Yumie Rhee, HyeonChang Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: Vitamin D deficiency is a common condition that is associated with diabetes and insulin resistance. However, the association between vitamin D and insulin resistance has not been fully studied, especially in the general adolescent population. Therefore, we assessed the association between serum 25-hydroxyvitamin D [25(OH)D] level and insulin resistance among apparently healthy Korean adolescents. Methods: A total of 260 (135 male and 125 female) adolescents in a rural high school were assessed for serum 25(OH)D, fasting plasma glucose, and insulin. All of the participants were aged 15 to 16 years old, and without known hypertension or diabetes. Serum 25(OH)D was analyzed both as a continuous and categorical variable in association with insulin resistance. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Increased insulin resistance was operationally defined as a HOMA-IR value higher than the sex-specific 75th percentile. Results: In male adolescents, every 10 ng/ml decrease in 25(OH)D level was associated with a 0.25 unit increase in HOMA-IR (p = 0.003) after adjusting for age and BMI. Compared to those in the highest quartile, male adolescents in the lowest 25(OH)D quartile were at significantly higher risk for insulin resistance: unadjusted odds ratio 4.06 (95% CI, 1.26 to 13.07); age and BMI adjusted odds ratio 3.59 (95% CI, 1.03 to 12.57). However, 25(OH)D level, either in continuous or categorical measure, was not significantly associated with insulin resistance among female adolescents. Conclusions: This study suggests that serum 25(OH)D level may be inversely associated with insulin resistance in healthy male adolescents.

Original languageEnglish
Article numbere103108
JournalPloS one
Volume9
Issue number7
DOIs
Publication statusPublished - 2014 Jul 29

Fingerprint

insulin resistance
Insulin Resistance
Insulin
Serum
odds ratio
Medical problems
diabetes
Vitamin D
Odds Ratio
25-hydroxyvitamin D
vitamin D deficiency
high schools
Vitamin D Deficiency
vitamin D
hypertension
fasting
Fasting
homeostasis
Homeostasis
insulin

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Choi, D. P., Oh, S. M., Lee, J. M., Cho, H. M., Lee, W. J., Song, B. M., ... Kim, H. (2014). Serum 25-hydroxyvitamin D and insulin resistance in apparently healthy adolescents. PloS one, 9(7), [e103108]. https://doi.org/10.1371/journal.pone.0103108
Choi, Dong Phil ; Oh, Sun Min ; Lee, Ju Mi ; Cho, Hye Min ; Lee, Won Joon ; Song, Bo Mi ; Rhee, Yumie ; Kim, HyeonChang. / Serum 25-hydroxyvitamin D and insulin resistance in apparently healthy adolescents. In: PloS one. 2014 ; Vol. 9, No. 7.
@article{8fb543d4de0f439ab604019fec3ef85d,
title = "Serum 25-hydroxyvitamin D and insulin resistance in apparently healthy adolescents",
abstract = "Purpose: Vitamin D deficiency is a common condition that is associated with diabetes and insulin resistance. However, the association between vitamin D and insulin resistance has not been fully studied, especially in the general adolescent population. Therefore, we assessed the association between serum 25-hydroxyvitamin D [25(OH)D] level and insulin resistance among apparently healthy Korean adolescents. Methods: A total of 260 (135 male and 125 female) adolescents in a rural high school were assessed for serum 25(OH)D, fasting plasma glucose, and insulin. All of the participants were aged 15 to 16 years old, and without known hypertension or diabetes. Serum 25(OH)D was analyzed both as a continuous and categorical variable in association with insulin resistance. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Increased insulin resistance was operationally defined as a HOMA-IR value higher than the sex-specific 75th percentile. Results: In male adolescents, every 10 ng/ml decrease in 25(OH)D level was associated with a 0.25 unit increase in HOMA-IR (p = 0.003) after adjusting for age and BMI. Compared to those in the highest quartile, male adolescents in the lowest 25(OH)D quartile were at significantly higher risk for insulin resistance: unadjusted odds ratio 4.06 (95{\%} CI, 1.26 to 13.07); age and BMI adjusted odds ratio 3.59 (95{\%} CI, 1.03 to 12.57). However, 25(OH)D level, either in continuous or categorical measure, was not significantly associated with insulin resistance among female adolescents. Conclusions: This study suggests that serum 25(OH)D level may be inversely associated with insulin resistance in healthy male adolescents.",
author = "Choi, {Dong Phil} and Oh, {Sun Min} and Lee, {Ju Mi} and Cho, {Hye Min} and Lee, {Won Joon} and Song, {Bo Mi} and Yumie Rhee and HyeonChang Kim",
year = "2014",
month = "7",
day = "29",
doi = "10.1371/journal.pone.0103108",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

Serum 25-hydroxyvitamin D and insulin resistance in apparently healthy adolescents. / Choi, Dong Phil; Oh, Sun Min; Lee, Ju Mi; Cho, Hye Min; Lee, Won Joon; Song, Bo Mi; Rhee, Yumie; Kim, HyeonChang.

In: PloS one, Vol. 9, No. 7, e103108, 29.07.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum 25-hydroxyvitamin D and insulin resistance in apparently healthy adolescents

AU - Choi, Dong Phil

AU - Oh, Sun Min

AU - Lee, Ju Mi

AU - Cho, Hye Min

AU - Lee, Won Joon

AU - Song, Bo Mi

AU - Rhee, Yumie

AU - Kim, HyeonChang

PY - 2014/7/29

Y1 - 2014/7/29

N2 - Purpose: Vitamin D deficiency is a common condition that is associated with diabetes and insulin resistance. However, the association between vitamin D and insulin resistance has not been fully studied, especially in the general adolescent population. Therefore, we assessed the association between serum 25-hydroxyvitamin D [25(OH)D] level and insulin resistance among apparently healthy Korean adolescents. Methods: A total of 260 (135 male and 125 female) adolescents in a rural high school were assessed for serum 25(OH)D, fasting plasma glucose, and insulin. All of the participants were aged 15 to 16 years old, and without known hypertension or diabetes. Serum 25(OH)D was analyzed both as a continuous and categorical variable in association with insulin resistance. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Increased insulin resistance was operationally defined as a HOMA-IR value higher than the sex-specific 75th percentile. Results: In male adolescents, every 10 ng/ml decrease in 25(OH)D level was associated with a 0.25 unit increase in HOMA-IR (p = 0.003) after adjusting for age and BMI. Compared to those in the highest quartile, male adolescents in the lowest 25(OH)D quartile were at significantly higher risk for insulin resistance: unadjusted odds ratio 4.06 (95% CI, 1.26 to 13.07); age and BMI adjusted odds ratio 3.59 (95% CI, 1.03 to 12.57). However, 25(OH)D level, either in continuous or categorical measure, was not significantly associated with insulin resistance among female adolescents. Conclusions: This study suggests that serum 25(OH)D level may be inversely associated with insulin resistance in healthy male adolescents.

AB - Purpose: Vitamin D deficiency is a common condition that is associated with diabetes and insulin resistance. However, the association between vitamin D and insulin resistance has not been fully studied, especially in the general adolescent population. Therefore, we assessed the association between serum 25-hydroxyvitamin D [25(OH)D] level and insulin resistance among apparently healthy Korean adolescents. Methods: A total of 260 (135 male and 125 female) adolescents in a rural high school were assessed for serum 25(OH)D, fasting plasma glucose, and insulin. All of the participants were aged 15 to 16 years old, and without known hypertension or diabetes. Serum 25(OH)D was analyzed both as a continuous and categorical variable in association with insulin resistance. Insulin resistance was estimated by homeostasis model assessment (HOMA-IR). Increased insulin resistance was operationally defined as a HOMA-IR value higher than the sex-specific 75th percentile. Results: In male adolescents, every 10 ng/ml decrease in 25(OH)D level was associated with a 0.25 unit increase in HOMA-IR (p = 0.003) after adjusting for age and BMI. Compared to those in the highest quartile, male adolescents in the lowest 25(OH)D quartile were at significantly higher risk for insulin resistance: unadjusted odds ratio 4.06 (95% CI, 1.26 to 13.07); age and BMI adjusted odds ratio 3.59 (95% CI, 1.03 to 12.57). However, 25(OH)D level, either in continuous or categorical measure, was not significantly associated with insulin resistance among female adolescents. Conclusions: This study suggests that serum 25(OH)D level may be inversely associated with insulin resistance in healthy male adolescents.

UR - http://www.scopus.com/inward/record.url?scp=84904978738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904978738&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0103108

DO - 10.1371/journal.pone.0103108

M3 - Article

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 7

M1 - e103108

ER -