Serum 25-hydroxyVitamin D levels and dry eye syndrome: Differential effects of Vitamin D on ocular diseases

The Epidemiologic Survey Committee of the Korean Ophthalmologic Society

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Abstract

Purpose. To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. Methods. A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations. DES was defined by a history of clinical diagnosis of dry eyes by a physician. The association between vitamin D and DES was compared to the associations between vitamin D and AMD, DR, cataract, and DES from our previous studies. Results. The odds of DES non-significantly decreased as the quintiles of serum 25-hydroxyvitamin D levels increased (quintile 5 versus 1, OR = 0.85, 95%CI: 0.55-1.30, P for trend = 0.076) after adjusting for potential confounders including age, sex, hypertension, diabetes, smoking status, and sunlight exposure times. The relative odds of DES (OR = 0.70, 95% CI: 0.30-1.64) and cataract (OR = 0.76, 95% CI: 0.59-0.99) were relatively high, while those of DR (OR = 0.37, 95% CI: 0.18-0.76) and late AMD (OR = 0.32, 95% CI: 0.12-0.81) were lower in men. Conclusions. The present study does not support an association between serum 25-hydroxyvitamin D levels and DES. The preventive effect of serum 25-hydroxyvitamin D may be more effective for DR and late AMD than it is for cataract and DES.

Original languageEnglish
Article numbere0149294
JournalPloS one
Volume11
Issue number2
DOIs
Publication statusPublished - 2016 Feb

Bibliographical note

Funding Information:
The authors would like to express their appreciation of the Epidemiologic Survey Committee of the Korean Ophthalmologic Society for conducting the KNHANES examinations and for supplying the data for this study. The authors wish to acknowledge the financial support of the St.Vincent’s hospital, research institute of medical science (SVHR-2013-12). The Epidemiologic Survey Committee of the Korean Ophthalmologic Society, the members are:

Publisher Copyright:
Copyright © 2016 Jee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

  • General

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