Serum 25-hydroxyVitamin D levels and dry eye syndrome

Differential effects of Vitamin D on ocular diseases

The Epidemiologic Survey Committee of the Korean Ophthalmologic Society

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose. To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. Methods. A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations. DES was defined by a history of clinical diagnosis of dry eyes by a physician. The association between vitamin D and DES was compared to the associations between vitamin D and AMD, DR, cataract, and DES from our previous studies. Results. The odds of DES non-significantly decreased as the quintiles of serum 25-hydroxyvitamin D levels increased (quintile 5 versus 1, OR = 0.85, 95%CI: 0.55-1.30, P for trend = 0.076) after adjusting for potential confounders including age, sex, hypertension, diabetes, smoking status, and sunlight exposure times. The relative odds of DES (OR = 0.70, 95% CI: 0.30-1.64) and cataract (OR = 0.76, 95% CI: 0.59-0.99) were relatively high, while those of DR (OR = 0.37, 95% CI: 0.18-0.76) and late AMD (OR = 0.32, 95% CI: 0.12-0.81) were lower in men. Conclusions. The present study does not support an association between serum 25-hydroxyvitamin D levels and DES. The preventive effect of serum 25-hydroxyvitamin D may be more effective for DR and late AMD than it is for cataract and DES.

Original languageEnglish
Article numbere0149294
JournalPloS one
Volume11
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Fingerprint

Dry Eye Syndromes
eye diseases
Eye Diseases
vitamin D
blood serum
Vitamin D
diabetic retinopathy
cataract
Serum
Diabetic Retinopathy
Cataract
Nutrition
Medical problems
eyes
Blood
25-hydroxyvitamin D
dry eye syndrome
Health
National Health and Nutrition Examination Survey
Nutrition Surveys

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

The Epidemiologic Survey Committee of the Korean Ophthalmologic Society. / Serum 25-hydroxyVitamin D levels and dry eye syndrome : Differential effects of Vitamin D on ocular diseases. In: PloS one. 2016 ; Vol. 11, No. 2.
@article{1bc12fc538724af986efb32e1e50e196,
title = "Serum 25-hydroxyVitamin D levels and dry eye syndrome: Differential effects of Vitamin D on ocular diseases",
abstract = "Purpose. To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. Methods. A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations. DES was defined by a history of clinical diagnosis of dry eyes by a physician. The association between vitamin D and DES was compared to the associations between vitamin D and AMD, DR, cataract, and DES from our previous studies. Results. The odds of DES non-significantly decreased as the quintiles of serum 25-hydroxyvitamin D levels increased (quintile 5 versus 1, OR = 0.85, 95{\%}CI: 0.55-1.30, P for trend = 0.076) after adjusting for potential confounders including age, sex, hypertension, diabetes, smoking status, and sunlight exposure times. The relative odds of DES (OR = 0.70, 95{\%} CI: 0.30-1.64) and cataract (OR = 0.76, 95{\%} CI: 0.59-0.99) were relatively high, while those of DR (OR = 0.37, 95{\%} CI: 0.18-0.76) and late AMD (OR = 0.32, 95{\%} CI: 0.12-0.81) were lower in men. Conclusions. The present study does not support an association between serum 25-hydroxyvitamin D levels and DES. The preventive effect of serum 25-hydroxyvitamin D may be more effective for DR and late AMD than it is for cataract and DES.",
author = "{The Epidemiologic Survey Committee of the Korean Ophthalmologic Society} and Donghyun Jee and Seungbum Kang and Changzheng Yuan and Eunyoung Cho and Arroyo, {Jorge G.} and Kang, {Se Woong} and Baek, {Seung Hee} and chanyun kim and Kim, {Sang Duck} and Kim, {Seung Hyun} and Lee, {Jong Soo} and Lim, {Key Hwan} and Park, {Ki Ho} and Park, {Young Jeung} and Shin, {Jae Pil} and Song, {Su Jeong} and Yang, {Suk Woo} and Yoon, {Kyung Chul} and Yu, {Seung Young}",
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The Epidemiologic Survey Committee of the Korean Ophthalmologic Society 2016, 'Serum 25-hydroxyVitamin D levels and dry eye syndrome: Differential effects of Vitamin D on ocular diseases', PloS one, vol. 11, no. 2, e0149294. https://doi.org/10.1371/journal.pone.0149294

Serum 25-hydroxyVitamin D levels and dry eye syndrome : Differential effects of Vitamin D on ocular diseases. / The Epidemiologic Survey Committee of the Korean Ophthalmologic Society.

In: PloS one, Vol. 11, No. 2, e0149294, 01.02.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum 25-hydroxyVitamin D levels and dry eye syndrome

T2 - Differential effects of Vitamin D on ocular diseases

AU - The Epidemiologic Survey Committee of the Korean Ophthalmologic Society

AU - Jee, Donghyun

AU - Kang, Seungbum

AU - Yuan, Changzheng

AU - Cho, Eunyoung

AU - Arroyo, Jorge G.

AU - Kang, Se Woong

AU - Baek, Seung Hee

AU - kim, chanyun

AU - Kim, Sang Duck

AU - Kim, Seung Hyun

AU - Lee, Jong Soo

AU - Lim, Key Hwan

AU - Park, Ki Ho

AU - Park, Young Jeung

AU - Shin, Jae Pil

AU - Song, Su Jeong

AU - Yang, Suk Woo

AU - Yoon, Kyung Chul

AU - Yu, Seung Young

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Purpose. To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. Methods. A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations. DES was defined by a history of clinical diagnosis of dry eyes by a physician. The association between vitamin D and DES was compared to the associations between vitamin D and AMD, DR, cataract, and DES from our previous studies. Results. The odds of DES non-significantly decreased as the quintiles of serum 25-hydroxyvitamin D levels increased (quintile 5 versus 1, OR = 0.85, 95%CI: 0.55-1.30, P for trend = 0.076) after adjusting for potential confounders including age, sex, hypertension, diabetes, smoking status, and sunlight exposure times. The relative odds of DES (OR = 0.70, 95% CI: 0.30-1.64) and cataract (OR = 0.76, 95% CI: 0.59-0.99) were relatively high, while those of DR (OR = 0.37, 95% CI: 0.18-0.76) and late AMD (OR = 0.32, 95% CI: 0.12-0.81) were lower in men. Conclusions. The present study does not support an association between serum 25-hydroxyvitamin D levels and DES. The preventive effect of serum 25-hydroxyvitamin D may be more effective for DR and late AMD than it is for cataract and DES.

AB - Purpose. To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. Methods. A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations. DES was defined by a history of clinical diagnosis of dry eyes by a physician. The association between vitamin D and DES was compared to the associations between vitamin D and AMD, DR, cataract, and DES from our previous studies. Results. The odds of DES non-significantly decreased as the quintiles of serum 25-hydroxyvitamin D levels increased (quintile 5 versus 1, OR = 0.85, 95%CI: 0.55-1.30, P for trend = 0.076) after adjusting for potential confounders including age, sex, hypertension, diabetes, smoking status, and sunlight exposure times. The relative odds of DES (OR = 0.70, 95% CI: 0.30-1.64) and cataract (OR = 0.76, 95% CI: 0.59-0.99) were relatively high, while those of DR (OR = 0.37, 95% CI: 0.18-0.76) and late AMD (OR = 0.32, 95% CI: 0.12-0.81) were lower in men. Conclusions. The present study does not support an association between serum 25-hydroxyvitamin D levels and DES. The preventive effect of serum 25-hydroxyvitamin D may be more effective for DR and late AMD than it is for cataract and DES.

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U2 - 10.1371/journal.pone.0149294

DO - 10.1371/journal.pone.0149294

M3 - Article

VL - 11

JO - PLoS One

JF - PLoS One

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