Serum adiponectin and protein–energy wasting in predialysis chronic kidney disease

Young Youl Hyun, Kyu Beck Lee, Kook Hwan Oh, Curie Ahn, Sue Kyung Park, Dong Wan Chae, TaeHyun Yoo, Kyu Hun Cho, Yong Soo Kim, Young Hwan Hwang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective Adiponectin (ADPN) has antiatherogenic, anti-inflammatory, and insulin-sensitizing effects. Serum ADPN levels are increased in patients with chronic kidney diseases (CKD), and higher ADPN is paradoxically a predictor of mortality in these patients. The aim of this study was to determine the association between serum ADPN levels and protein–energy wasting (PEW) in predialysis CKD. Method We examined serum ADPN concentrations and PEW in 1303 patients from the KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease) study. PEW was defined as the presence of three or more of the following four indicators: serum albumin <3.8 g/dL, body mass index <23 kg/m2, urine creatinine excretion (UCE) below the lower quartile, and daily dietary protein intake <0.6 g/kg. We analyzed the association between PEW and ADPN using a multivariate regression model after adjustment for socioeconomic factors, comorbidities, and laboratory findings. Results Among 1303 predialysis CKD patients, 72 (5.5%) had PEW. In multivariate logistic regression analysis, higher ADPN level was associated with PEW (odds ratio, 1.04; 95% confidence interval [CI], 1.01–1.08 by 1 μg/mL ADPN). The highest ADPN quartile was associated with PEW in comparison with the lowest quartile (odds ratio, 10.54; 95% CI, 1.28–86.74). In multiple linear regression with PEW indicators, ADPN was more strongly associated with UCE (β = −2.21; 95% CI, −4.13 to −0.28; R2 = 0.67). Conclusion High ADPN is independently associated with PEW. Among PEW indicators, serum ADPN is closely associated with UCE as an indirect measure of muscle mass.

Original languageEnglish
Pages (from-to)254-260
Number of pages7
JournalNutrition
Volume33
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

Adiponectin
Chronic Renal Insufficiency
Serum
Creatinine
Urine
Confidence Intervals
Odds Ratio
Dietary Proteins
Serum Albumin
Comorbidity
Linear Models
Body Mass Index
Cohort Studies
Anti-Inflammatory Agents
Logistic Models
Regression Analysis
Insulin

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Hyun, Y. Y., Lee, K. B., Oh, K. H., Ahn, C., Park, S. K., Chae, D. W., ... Hwang, Y. H. (2017). Serum adiponectin and protein–energy wasting in predialysis chronic kidney disease. Nutrition, 33, 254-260. https://doi.org/10.1016/j.nut.2016.06.014
Hyun, Young Youl ; Lee, Kyu Beck ; Oh, Kook Hwan ; Ahn, Curie ; Park, Sue Kyung ; Chae, Dong Wan ; Yoo, TaeHyun ; Cho, Kyu Hun ; Kim, Yong Soo ; Hwang, Young Hwan. / Serum adiponectin and protein–energy wasting in predialysis chronic kidney disease. In: Nutrition. 2017 ; Vol. 33. pp. 254-260.
@article{37f3eea8dc424f48a94abfe6a9a9bb7a,
title = "Serum adiponectin and protein–energy wasting in predialysis chronic kidney disease",
abstract = "Objective Adiponectin (ADPN) has antiatherogenic, anti-inflammatory, and insulin-sensitizing effects. Serum ADPN levels are increased in patients with chronic kidney diseases (CKD), and higher ADPN is paradoxically a predictor of mortality in these patients. The aim of this study was to determine the association between serum ADPN levels and protein–energy wasting (PEW) in predialysis CKD. Method We examined serum ADPN concentrations and PEW in 1303 patients from the KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease) study. PEW was defined as the presence of three or more of the following four indicators: serum albumin <3.8 g/dL, body mass index <23 kg/m2, urine creatinine excretion (UCE) below the lower quartile, and daily dietary protein intake <0.6 g/kg. We analyzed the association between PEW and ADPN using a multivariate regression model after adjustment for socioeconomic factors, comorbidities, and laboratory findings. Results Among 1303 predialysis CKD patients, 72 (5.5{\%}) had PEW. In multivariate logistic regression analysis, higher ADPN level was associated with PEW (odds ratio, 1.04; 95{\%} confidence interval [CI], 1.01–1.08 by 1 μg/mL ADPN). The highest ADPN quartile was associated with PEW in comparison with the lowest quartile (odds ratio, 10.54; 95{\%} CI, 1.28–86.74). In multiple linear regression with PEW indicators, ADPN was more strongly associated with UCE (β = −2.21; 95{\%} CI, −4.13 to −0.28; R2 = 0.67). Conclusion High ADPN is independently associated with PEW. Among PEW indicators, serum ADPN is closely associated with UCE as an indirect measure of muscle mass.",
author = "Hyun, {Young Youl} and Lee, {Kyu Beck} and Oh, {Kook Hwan} and Curie Ahn and Park, {Sue Kyung} and Chae, {Dong Wan} and TaeHyun Yoo and Cho, {Kyu Hun} and Kim, {Yong Soo} and Hwang, {Young Hwan}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.nut.2016.06.014",
language = "English",
volume = "33",
pages = "254--260",
journal = "Nutrition",
issn = "0899-9007",
publisher = "Elsevier Inc.",

}

Hyun, YY, Lee, KB, Oh, KH, Ahn, C, Park, SK, Chae, DW, Yoo, T, Cho, KH, Kim, YS & Hwang, YH 2017, 'Serum adiponectin and protein–energy wasting in predialysis chronic kidney disease', Nutrition, vol. 33, pp. 254-260. https://doi.org/10.1016/j.nut.2016.06.014

Serum adiponectin and protein–energy wasting in predialysis chronic kidney disease. / Hyun, Young Youl; Lee, Kyu Beck; Oh, Kook Hwan; Ahn, Curie; Park, Sue Kyung; Chae, Dong Wan; Yoo, TaeHyun; Cho, Kyu Hun; Kim, Yong Soo; Hwang, Young Hwan.

In: Nutrition, Vol. 33, 01.01.2017, p. 254-260.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum adiponectin and protein–energy wasting in predialysis chronic kidney disease

AU - Hyun, Young Youl

AU - Lee, Kyu Beck

AU - Oh, Kook Hwan

AU - Ahn, Curie

AU - Park, Sue Kyung

AU - Chae, Dong Wan

AU - Yoo, TaeHyun

AU - Cho, Kyu Hun

AU - Kim, Yong Soo

AU - Hwang, Young Hwan

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective Adiponectin (ADPN) has antiatherogenic, anti-inflammatory, and insulin-sensitizing effects. Serum ADPN levels are increased in patients with chronic kidney diseases (CKD), and higher ADPN is paradoxically a predictor of mortality in these patients. The aim of this study was to determine the association between serum ADPN levels and protein–energy wasting (PEW) in predialysis CKD. Method We examined serum ADPN concentrations and PEW in 1303 patients from the KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease) study. PEW was defined as the presence of three or more of the following four indicators: serum albumin <3.8 g/dL, body mass index <23 kg/m2, urine creatinine excretion (UCE) below the lower quartile, and daily dietary protein intake <0.6 g/kg. We analyzed the association between PEW and ADPN using a multivariate regression model after adjustment for socioeconomic factors, comorbidities, and laboratory findings. Results Among 1303 predialysis CKD patients, 72 (5.5%) had PEW. In multivariate logistic regression analysis, higher ADPN level was associated with PEW (odds ratio, 1.04; 95% confidence interval [CI], 1.01–1.08 by 1 μg/mL ADPN). The highest ADPN quartile was associated with PEW in comparison with the lowest quartile (odds ratio, 10.54; 95% CI, 1.28–86.74). In multiple linear regression with PEW indicators, ADPN was more strongly associated with UCE (β = −2.21; 95% CI, −4.13 to −0.28; R2 = 0.67). Conclusion High ADPN is independently associated with PEW. Among PEW indicators, serum ADPN is closely associated with UCE as an indirect measure of muscle mass.

AB - Objective Adiponectin (ADPN) has antiatherogenic, anti-inflammatory, and insulin-sensitizing effects. Serum ADPN levels are increased in patients with chronic kidney diseases (CKD), and higher ADPN is paradoxically a predictor of mortality in these patients. The aim of this study was to determine the association between serum ADPN levels and protein–energy wasting (PEW) in predialysis CKD. Method We examined serum ADPN concentrations and PEW in 1303 patients from the KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease) study. PEW was defined as the presence of three or more of the following four indicators: serum albumin <3.8 g/dL, body mass index <23 kg/m2, urine creatinine excretion (UCE) below the lower quartile, and daily dietary protein intake <0.6 g/kg. We analyzed the association between PEW and ADPN using a multivariate regression model after adjustment for socioeconomic factors, comorbidities, and laboratory findings. Results Among 1303 predialysis CKD patients, 72 (5.5%) had PEW. In multivariate logistic regression analysis, higher ADPN level was associated with PEW (odds ratio, 1.04; 95% confidence interval [CI], 1.01–1.08 by 1 μg/mL ADPN). The highest ADPN quartile was associated with PEW in comparison with the lowest quartile (odds ratio, 10.54; 95% CI, 1.28–86.74). In multiple linear regression with PEW indicators, ADPN was more strongly associated with UCE (β = −2.21; 95% CI, −4.13 to −0.28; R2 = 0.67). Conclusion High ADPN is independently associated with PEW. Among PEW indicators, serum ADPN is closely associated with UCE as an indirect measure of muscle mass.

UR - http://www.scopus.com/inward/record.url?scp=85003706957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85003706957&partnerID=8YFLogxK

U2 - 10.1016/j.nut.2016.06.014

DO - 10.1016/j.nut.2016.06.014

M3 - Article

C2 - 27692989

AN - SCOPUS:85003706957

VL - 33

SP - 254

EP - 260

JO - Nutrition

JF - Nutrition

SN - 0899-9007

ER -